Evaluation and adapting of a new technology to monitor blood viscoelastic properties

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Rheolution Inc. manufactures contactless mechanical characterization instruments for real-time measurement**of viscoelastic/rheological properties of liquids and soft materials. The instruments are used in the food**industry (e.g., milk coagulation), and to a limited extent, in academia and industries focused on biomaterial and**medical device technologies (e.g., hydrogels). The company is exploring the potential expansion of its markets**by investigating its technology in measuring changes in blood biomechanics and correlating these with**coagulation kinetics. The Aim of this NSERC Engage project is to solve the company problem in identifying**the blood biocompatibility of the materials used in its sample holders and optimizing the sensitivity of its**technology in characterizing blood coagulation. Quantitative real-time measurements of whole blood**viscoelastic properties will be correlated with established in vitro assays of coagulation at different**length-scales. It is anticipated that this will help enable Rheolution to undertake further research and**development in modifying its instruments for potential applications in measuring blood coagulation. Ultimately**the goal of Rheolution is to supply its equipment to clinical practices such as hospitals, as well as industries**focused on developing blood coagulants or anticoagulants.