Evaluation and adapting of a new technology to monitor blood viscoelastic properties

监测血液粘弹性特性新技术的评估和应用

• 批准号: 528815-2018
• 负责人: Nazhat, Showan
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=660729
• 关键词: Evaluation; adapting; new; technology; monitor

Rheolution Inc. manufactures contactless mechanical characterization instruments for real-time measurement**of viscoelastic/rheological properties of liquids and soft materials. The instruments are used in the food**industry (e.g., milk coagulation), and to a limited extent, in academia and industries focused on biomaterial and**medical device technologies (e.g., hydrogels). The company is exploring the potential expansion of its markets**by investigating its technology in measuring changes in blood biomechanics and correlating these with**coagulation kinetics. The Aim of this NSERC Engage project is to solve the company problem in identifying**the blood biocompatibility of the materials used in its sample holders and optimizing the sensitivity of its**technology in characterizing blood coagulation. Quantitative real-time measurements of whole blood**viscoelastic properties will be correlated with established in vitro assays of coagulation at different**length-scales. It is anticipated that this will help enable Rheolution to undertake further research and**development in modifying its instruments for potential applications in measuring blood coagulation. Ultimately**the goal of Rheolution is to supply its equipment to clinical practices such as hospitals, as well as industries**focused on developing blood coagulants or anticoagulants.

Rheolution Inc. 生产非接触式机械表征仪器，用于实时测量**液体和软材料的粘弹性/流变特性。这些仪器用于食品**行业（例如凝乳），并在一定程度上用于专注于生物材料和**医疗器械技术（例如水凝胶）的学术界和行业。该公司正在通过研究其测量血液生物力学变化的技术并将其与**凝血动力学联系起来，探索其市场的潜在扩张**。 NSERC Engage 项目的目的是解决公司在确定**其样本支架中使用的材料的血液生物相容性以及优化其**技术在表征血液凝固方面的灵敏度方面的问题。全血**粘弹性特性的定量实时测量将与已建立的不同**长度尺度的体外凝血测定相关联。预计这将有助于 Rheolution 进行进一步的研究和开发，修改其仪器，以实现测量凝血的潜在应用。最终**Rheolution 的目标是向医院等临床实践以及专注于开发凝血剂或抗凝剂的行业**提供其设备。