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Hypoxia-activated DNA repair inhibitors to improve cancer therapy

Hypoxia-activated DNA repair inhibitors to improve cancer therapy
缺氧激活 DNA 修复抑制剂可改善癌症治疗
批准号：
403718
负责人：
Minchinton Andrew I
金额：
$41.8万
依托单位：
B.C. Cancer Research Centre (Vancouver)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-03-01 至 2022-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=403718&lang=en
关键词：
Anti Cancer Drug Development Chemotherapy Dna Damage Repair Dna-Pk Drug Development Hypoxia Prodrugs Radiation Biology Radiotherapy Tumour Microenvironment

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英文摘要
It has been known for decades that the presence of cells with little or no oxygen causes resistance to both radiotherapy and chemotherapy. These 'hypoxic' cells result from the proliferation of cancer cells beyond the ability of the blood vessels to suppl
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Development of clinical candidate hypoxia-activated DNA-PK inhibitors
FLASH radiotherapy - mechanisms and translational studies
Metabolic manipulation of hypoxia for improved radiotherapy response
Hypoxia-selective inhibitors of DNA repair
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