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Hypoxia-selective inhibitors of DNA repair

Hypoxia-selective inhibitors of DNA repair
DNA 修复的缺氧选择性抑制剂
批准号:
376328
负责人:
Minchinton Andrew I
金额:
$18.9万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-11-01 至 2020-11-01

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英文摘要
The proposed work involves the development of a drug that will improve the effectiveness of radiation therapy. Since radiation therapy is used to treat about 50% of all cancers this drug could have very wide impact, improving cure rates as well as quality
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会议论文
Development of clinical candidate hypoxia-activated DNA-PK inhibitors
FLASH radiotherapy - mechanisms and translational studies
Metabolic manipulation of hypoxia for improved radiotherapy response
Hypoxia-activated DNA repair inhibitors to improve cancer therapy
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