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FLASH radiotherapy - mechanisms and translational studies

FLASH radiotherapy - mechanisms and translational studies
FLASH 放射治疗 - 机制和转化研究
批准号：
444863
负责人：
Minchinton Andrew I
金额：
$66.88万
依托单位：
B.C. Cancer Research Centre (Vancouver)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-04-01 至 2025-04-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=444863&lang=en
关键词：
Drug Distribution Flash Radiation Hypoxia Normal Tissue Toxicity Oxygen Consumption Radiation Resistance Therapeutic Index Tumour Microenvironment Tumour Oxygenation Ultra High Dose Radiotherapy

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英文摘要
The effectiveness of radiotherapy is determined by normal tissue tolerance. In other words, the dose of radiation administered to the tumour is determined by how well the 'normal' tissue within the irradiated beam can tolerate the dose. Over decades the m
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Development of clinical candidate hypoxia-activated DNA-PK inhibitors
Metabolic manipulation of hypoxia for improved radiotherapy response
Hypoxia-activated DNA repair inhibitors to improve cancer therapy
Hypoxia-selective inhibitors of DNA repair
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