Metabolic manipulation of hypoxia for improved radiotherapy response

缺氧的代谢控制可改善放疗反应

• 批准号: 451372
• 负责人: Minchinton Andrew I
• 金额: $ 49.32万
• 依托单位: B.C. Cancer Research Centre (Vancouver)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-09-01 至 2025-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=451372&lang=en
• 关键词: Drug Screening; Glycolytic Blockade; Hypoxia; Metabolic Reprogramming; Mitochondria Inhibitors; Prodrugs; Radiotherapy; Re-Oxygenation; Respiratory Chain Inhibitors; Tumour Microenvironment

Despite over a hundred years of research there is still no Health Canada/FDA approved drug that can be taken at the time of radiotherapy to improve treatment outcome without increasing side effects in non-cancer tissues. Radiotherapy improvements have lar

尽管有一百多年的研究，仍然没有加拿大卫生部/FDA批准的药物可以在放射治疗时服用，以改善治疗结果，而不会增加非癌组织的副作用。放射治疗的改善有很大的