Evaluation of interferences and development of robust protocols for Surface Enhanced Raman Spectroscopy Detection of Fentanyl and analogous molecules

芬太尼和类似分子表面增强拉曼光谱检测干扰的评估和稳健方案的开发

• 批准号: 544049-2019
• 负责人: Rutter, Allison
• 金额: $ 1.82万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680687
• 关键词: Evaluation; interferences; development; robust; protocols

In Canada, the availability of illicit drugs represents a major public health and safety risk. In particular, contamination of these drugs with Fentanyl has been implicated in thousands of deaths in Canada in the last few years. Spectra Plasmonics has developed a promising new method for the detection of Fentanyl and other illicit drugs based on their proprietary sensor technology. This new technology (Surface Enhanced Raman Spectroscopy) would provide accurate, portable and cost-effective analysis of Fentanyl in drug samples. Spectra Plasmonics has prototype sensors for this exciting technique however needs assistance to evaluate the effect of potential interferences such as cutting agents and other opioids such as heroin and oxycodone. This grant will fund the academic expertise required to elucidate the mechanisms of these interferences and develop robust methods which will work in real world scenarios. Accurate on-site detection of Fentanyl in multidrug formulations will fill a crucial gap in the public health and safety of Canadians.

在加拿大，非法药物的供应是一个重大的公共健康和安全风险。特别是，在过去几年中，这些药物与芬太尼的污染在加拿大造成了数千人死亡。Spectra Plasmonics开发了一种基于其专有传感器技术检测芬太尼和其他非法药物的有前途的新方法。这项新技术（表面增强拉曼光谱）将提供准确、便携和具有成本效益的药物样品芬太尼分析。Spectra Plasmonics拥有用于这项令人兴奋的技术的原型传感器，但需要帮助来评估潜在干扰的影响，如切割剂和其他阿片类药物，如海洛因和羟考酮。该补助金将资助阐明这些干扰机制所需的学术专业知识，并开发出适用于真实的世界场景的强大方法。准确的现场检测多药制剂中的芬太尼将填补加拿大人公共卫生和安全方面的一个关键空白。