Biomaterials to Reduce Ocular Surface Inflammatory Response

减少眼表炎症反应的生物材料

• 批准号: RGPIN-2017-03795
• 负责人: Jones, Lyndon
• 金额: $ 2.04万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=682124
• 关键词: Biomaterials; Reduce; Ocular; Surface; Inflammatory

Biomaterials are materials that come into close contact*with living biological cells or fluids. Some of the best examples of*biomaterials include heart valves, blood vessels, artificial joint*replacements, breast implants, intraocular lens implants (for use following*cataract surgery), and contact lenses, of which the latter two are among the*most widely used. Over 140 million people worldwide wear contact lenses, of*which 90% use soft, hydrogel lenses, which are typically replaced after being*used for 1 day to 1 month. In Canada alone, the 3 million wearers of*lenses use approximately 30 million new soft lenses annually. These*materials come into direct contact with the tear film on the surface of the*eye, which is a highly complex fluid containing a wide variety of proteins,*oils, metabolites and electrolytes. Once exposed to the tear film, these*contact lens materials take up various components from it, some of which may*induce inflammatory responses. ***This grant will continue my work in developing an*enhanced understanding of the interactions that occur between soft lens*materials with the tear film and outer surface of the eye. It will use a wide variety*of cutting-edge laboratory techniques, with a specific emphasis of trying to*better understand contact lens-induced inflammation. ***Two specific programs of work will be undertaken:***a) *To develop a better understanding of the way*that certain pro-inflammatory substances in the tear film result in*inflammation. Once this has been determined then we will develop new materials*that resist the uptake of these components.***b) *To develop novel materials that deliver*anti-inflammatory substances to the surface of the eye. These will include examination*of the potential for substances shown to be beneficial when ingested, such as vitamin*C, resveratrol (found in red wine), components in green tea and omega 3 essential*fatty acids.***Obtaining a greater understanding of the potential for contact*lens materials to cause and modify ocular surface inflammation will help with*the development of next generation contact lens materials and other ocular*biomaterials. The results will provide excellent training for Canadian students*in an area that provides great potential for employment, and will lead to*better contact lens materials for the 3 million Canadians who wear contacts.******

生物材料是与活的生物细胞或液体密切接触的材料。一些最好的生物材料包括心脏瓣膜、血管、人工关节置换、乳房植入物、眼内透镜植入物（用于白内障手术后）和隐形眼镜，其中后两种是最广泛使用的。全球有超过1.4亿人佩戴隐形眼镜，其中90%* 使用软性水凝胶镜片，通常在 * 使用1天至1个月后更换。仅在加拿大，300万 * 镜片配戴者每年使用约3000万新的软性镜片。这些物质与眼睛表面的泪膜直接接触，泪膜是一种高度复杂的液体，含有各种蛋白质、油脂、代谢物和电解质。一旦接触到泪膜，这些透镜材料就会吸收泪膜中的各种成分，其中一些可能会引起炎症反应。* 这项资助将继续我的工作，以提高对软透镜 * 材料与泪液膜和眼睛外表面之间相互作用的理解。它将使用各种各样的尖端实验室技术，特别强调试图更好地了解隐形眼镜引起的炎症。* 将开展两项具体的工作方案：*a） * 更好地了解泪膜中某些促炎物质导致炎症的方式。一旦确定了这一点，我们将开发新材料 *，以抵抗这些成分的吸收。B） * 开发新型材料，将 * 抗炎物质输送到眼睛表面。这些将包括检查 * 摄入时显示有益的物质的潜力，如维生素 *C，白藜芦醇（在红葡萄酒中发现），绿色茶和欧米茄3必需脂肪酸中的成分。深入了解接触性透镜材料引起和改变眼表炎症的潜力将有助于开发下一代接触性透镜材料和其他眼用生物材料。研究结果将为加拿大学生 * 在一个提供巨大就业潜力的领域提供出色的培训，并将为300万戴隐形眼镜的加拿大人 ** 提供更好的隐形透镜材料。