Biomaterials to Reduce Ocular Surface Inflammatory Response

减少眼表炎症反应的生物材料

• 批准号: RGPIN-2017-03795
• 负责人: Jones, Lyndon
• 金额: $ 2.04万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=710533
• 关键词: Biomaterials; Reduce; Ocular; Surface; Inflammatory

Biomaterials are materials that come into close contact with living biological cells or fluids. Some of the best examples of biomaterials include heart valves, blood vessels, artificial joint replacements, breast implants, intraocular lens implants (for use following cataract surgery), and contact lenses, of which the latter two are among the most widely used. Over 140 million people worldwide wear contact lenses, of which 90% use soft, hydrogel lenses, which are typically replaced after being used for 1 day to 1 month. In Canada alone, the 3 million wearers of lenses use approximately 30 million new soft lenses annually. These materials come into direct contact with the tear film on the surface of the eye, which is a highly complex fluid containing a wide variety of proteins, oils, metabolites and electrolytes. Once exposed to the tear film, these contact lens materials take up various components from it, some of which may induce inflammatory responses. This grant will continue my work in developing an enhanced understanding of the interactions that occur between soft lens materials with the tear film and outer surface of the eye. It will use a wide variety of cutting-edge laboratory techniques, with a specific emphasis of trying to better understand contact lens-induced inflammation. Two specific programs of work will be undertaken: a) To develop a better understanding of the way that certain pro-inflammatory substances in the tear film result in inflammation. Once this has been determined then we will develop new materials that resist the uptake of these components. b) To develop novel materials that deliver anti-inflammatory substances to the surface of the eye. These will include examination of the potential for substances shown to be beneficial when ingested, such as vitamin C, resveratrol (found in red wine), components in green tea and omega 3 essential fatty acids. Obtaining a greater understanding of the potential for contact lens materials to cause and modify ocular surface inflammation will help with the development of next generation contact lens materials and other ocular biomaterials. The results will provide excellent training for Canadian students in an area that provides great potential for employment, and will lead to better contact lens materials for the 3 million Canadians who wear contacts.

生物材料是与生物体紧密接触的材料 活的生物细胞或液体。一些最好的例子， 生物材料包括心脏瓣膜、血管、人工关节 替代品、乳房植入物、眼内透镜植入物（以下使用 白内障手术）和隐形眼镜，其中后两者是其中之一。 最广泛使用。全球有超过1.4亿人佩戴隐形眼镜， 90%的人使用柔软的水凝胶镜片，通常在 使用1天至1个月。仅在加拿大，就有300万人佩戴 镜片每年使用大约3000万个新的软性镜片。这些 材料直接接触到的泪膜表面上的 眼睛是一种高度复杂的液体，含有多种蛋白质， 油、代谢物和电解质。一旦接触到泪膜， 接触透镜材料从中吸收各种成分，其中一些可以 诱导炎症反应。 这笔赠款将继续我的工作，在开发一个 增强了对软透镜之间发生的相互作用的理解 材料与泪膜和眼睛的外表面。它将使用各种各样的 尖端的实验室技术，特别强调试图 更好地了解隐形眼镜引起的炎症。 将开展两项具体的工作方案： a）、 为了更好地理解 泪膜中的某些促炎物质会导致 炎症一旦确定了这一点，我们将开发新材料 抵抗这些成分的吸收。 B） 开发新的材料， 抗炎物质到眼睛表面。其中包括考试 潜在的物质被证明是有益的，当摄入，如维生素 白藜芦醇（存在于红葡萄酒中），绿色茶中的成分和欧米伽3必需品 脂肪酸 更深入地了解接触的可能性 透镜材料引起和改变眼表炎症将有助于 下一代接触透镜材料和其它眼用材料的开发 生物材料研究结果将为加拿大学生提供出色的培训 在一个提供巨大就业潜力的领域， 为300万戴隐形眼镜的加拿大人提供更好的隐形透镜材料。