Effects of a low humidity environment and visual tasking on tear film protein composition

低湿度环境和视觉任务对泪膜蛋白质组成的影响

• 批准号: 445977-2012
• 负责人: Jones, Lyndon
• 金额: $ 1.82万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=511169
• 关键词: Effects; low; humidity; environment; visual

Tears are a readily available body fluid that can be easily collected without causing any discomfort to the patient. The collected tears can be analyzed in the laboratory and the results obtained from this analysis have the potential to tell us a great deal about our health. Tear tests, such as the level of various proteins, are used to determine whether people have ocular problems such as dry eye. Inflamax Research Inc is a Canadian company which has developed an Environmental Exposure Chamber (EEC) at 3121 Universal Drive, Mississauga, Ontario, which is one of only a handful designed for ocular research in the world and the only one in Canada. The EEC is an innovative facility designed to control temperature, RH and air flow in order to establish standardized and reproducible environments for the study of dry eye. Tears will be collected from patients before and exposure in the environmental chamber and tears will be analyzed using novel techniques in the Centre for Contact Lens Research Biological Sciences laboratory and the differences in these conditions will be studied. The results from this project will provide valuable data on the role of controlled humidity, temperature, airflow, lighting and visual tasking in altering the tear film protein composition and the results from this study will have important biotechnology and biomedical applications for Canada.

眼泪是一种容易获得的体液，可以很容易地收集而不会给患者造成任何不适。收集的眼泪可以在实验室中进行分析，从这种分析中获得的结果有可能告诉我们很多关于我们健康的信息。泪液测试，如各种蛋白质的水平，用于确定人们是否有眼部问题，如干眼症。Inflamax Research Inc是一家加拿大公司，该公司在安大略密西索加3121 Universal Drive开发了一个环境暴露室（EEC），这是世界上为数不多的几个专为眼科研究设计的环境暴露室之一，也是加拿大唯一的环境暴露室。EEC是一种创新的设备，旨在控制温度、相对湿度和气流，以便为干眼研究建立标准化和可重复的环境。将在接触环境室之前收集患者的泪液，并在接触透镜研究中心生物科学实验室使用新技术分析泪液，并研究这些条件的差异。该项目的结果将提供有关控制湿度，温度，气流，照明和视觉任务在改变泪膜蛋白质组成中的作用的有价值的数据，该研究的结果将为加拿大提供重要的生物技术和生物医学应用。