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Cytation Cell Imaging Multi-Mode Reader

Cytation 细胞成像多模式读取器

基本信息

批准号：
RTI-2017-00133
负责人：
Jones, Lyndon
金额：
$ 10.51万
依托单位：
University of Waterloo
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments
财政年份：
2016
资助国家：
加拿大
起止时间：
2016-01-01 至 2017-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=616568
关键词：
Cytation Cell Imaging Multi Mode

项目摘要

Summary of Proposal for Public Release The University of Waterloo requires a Cytation 5 Cell Imaging and Multi-Mode reader that combines automated digital microscopy with multi-mode microplate bioreader that is able to provide phenotypic cellular information and quantitative measurements of cell biochemistry. This is required for conducting research on the efficacy and tolerability of new medical device materials and pharmaceuticals. This reader is a new instrument that provides high quality imaging at the cellular and subcellular levels in both 2D and 3D. Imaging combined with quantitative information provides phenotypic cellular information with assessments of changes in cell metabolism and cell physiology. This system will serve nine faculty members in five different Departments/Schools at the University of Waterloo, namely Optometry, Pharmacy, Systems Design Engineering, Chemical Engineering and Kinesiology. Cytotoxicity and cell functionality assays are a crucial part of medical device and bio-pharmaceutical evaluations. This proposed system allows for the fusion of imaging and quantitative assessments of a wide array of fluorescent probes which allows for rich visualization and multiple quantitative assessments to be performed on the same cells. These features offer substantial advantages over traditional cytotoxicity measurements, that can assess only a few physiological effects at one time. This instrument will greatly enhance the University of Waterloo’s capabilities for detecting the effects of chemicals and biomaterials on cells and tissues.

公开发布建议书摘要滑铁卢大学需要一台Cytation 5细胞成像和多模式阅读器，该阅读器结合了自动数字显微镜和能够提供表型细胞信息和细胞生化定量测量的多模式微型平板生物阅读器。这是进行新的医疗器械材料和药物的有效性和耐受性研究所必需的。这个阅读器是一种新的仪器，在2D和3D的细胞和亚细胞水平上提供高质量的成像。成像结合定量信息提供表型细胞信息以及对细胞新陈代谢和细胞生理变化的评估。该系统将为滑铁卢大学五个不同系/学院的九名教职员工提供服务，这五个系分别是验光、药剂学、系统设计工程、化学工程和运动学。细胞毒性和细胞功能分析是医疗器械和生物制药评价的重要组成部分。这一拟议的系统允许融合各种荧光探针的成像和定量评估，从而允许对同一细胞进行丰富的可视化和多个定量评估。与传统的细胞毒性测量相比，这些功能提供了实质性的优势，因为传统的细胞毒性测量一次只能评估几个生理效应。该仪器将大大提高滑铁卢大学检测化学物质和生物材料对细胞和组织影响的能力。