Designing, developing and validating advanced materials and surface modifications for innovative biomaterials and implants

在过去的几十年里，生物材料已经成功地改善了数百万人的生活质量。然而，很少有生物材料和医疗设备的应用是完全成功的。失败或临床并发症经常被观察到，不同的发生率与应用有关。这个发现计划是非常坚实的基础上，先进的材料科学和工程方面应用于健康，特别是医疗领域。提出的长期愿景是深化和巩固一个新的3块研究计划：1)研究允许开发高附着力和强粘性涂层的参数，主要基于等离子体表面改性的金属器件；2)设计一类新的生物可吸收金属专用于临时装置；3)开发新的策略来测试、评估和预测新开发的涂层和金属植入人体后的生物性能。区块1和区块2的总体目标是在短期内（1至5年）提供新涂层和新材料，以提高医疗器械的临床性能。block 3的总体目标是在中期（5至10年）产生先进的（人类）细胞体外替代（动物）体内试验。这项研究极具原创性和创新性，可能会在评估新开发的涂层和材料的命运和影响方面取得突破性进展，这些涂层和材料用于从人类成人细胞中组织再生的生理和病理3D培养血管壁模型。由此产生的原始科学知识肯定会改进风险评估，并支持政府机构制定监管指南。此外，拟议的研究项目计划产生一个多价多方面（涂层-材料-测试）平台，易于应用于其他领域和应用，其中需要具有目标性能的专门设计的材料和涂层。在这一建议中，我们既提高了知识，又在加拿大的关键优势领域培养了高素质的人才。我们的研究环境是特殊的，特别是适应新的全球市场和我们今天所面临的挑战。自2015年以来，我们培训了100多名HQP：今天，他们通过使用我们培训的日常先进知识，领导力，快速适应技能，全球网络连接和战略思维，在学术界，工业界和政府中担任职务。总之，我们的实验室被公认为影响修复外科的临床和工业实践，并打开生物材料科学的新大门，为新发明申请专利和提出许可，欢迎成熟的和年轻的科学家在国际会议上发表演讲，与世界学术界和工业界的领导人密切合作，并定期协助向政府监管机构提供建议。

In the last decades, biomaterials have been successful to improve quality of the life for millions. However, very rare are the applications for which biomaterials and medical devices are completely successful. Failures or clinical complications are often observed, with different incidences related to the applications. This discovery program is very solidly based on advancing material science and engineering aspects applied to health, and in particular to the medical field. The proposed long-term vision is to deepen and consolidate a new 3 blocks-research program for: 1) investigating the parameters allowing the development of a highly-adherent and strongly-cohesive coating mainly based on plasma-based surface modification for metallic devices; 2) designing a new class of bioabsorbable metals specific for temporary devices; and 3) developing new strategies for testing, assessing and predicting the biological performances of the newly developed coatings and metals when implanted in humans. The overall goal of blocks 1 and 2 is to provide, at short term (1 to 5 years), new coatings and new materials to improve the clinical performances of medical devices. The overall goal of block 3 is to generate at medium term (5 to 10 years) advanced (human) cell-based in vitro alternative to (animal) in vivo tests. This research is extremely original and innovative and is likely to lead the ground-breaking advances in assessing the fate and impacts of newly-developed coatings and materials in a tissue-regenerated physio- and patho-logical 3D cultured vascular wall models from human adult cells. The original scientific knowledge generated is sure to improve risk assessments and support the development of regulatory guidelines by government agencies. Moreover, the proposed research program is planned to result in a polyvalent multi-facetted (coatings-materials-tests) platform susceptible to be applied to other fields and applications, where specifically-designed materials and coatings with targeted properties are required. In this proposal, we both advance knowledge and train high quality personnel in key areas of strength for Canada. Our research environment is exceptional and particularly adapted to meet the new Global market and challenges we are facing today. More than 100 HQP were trained since 2015: Today, they pursue positions in academia, industry and government by using daily advanced knowledge, leadership, fast adaptive skills, global network connections and strategic thinking for which they have been trained with us. In conclusion, our Laboratory is recognized to impact the clinical and industrial practice in reparative surgery, and to open new doors in Biomaterials Science, patent new inventions and propose licenses, welcome established and young scientists with invited lectures at international conferences, closely collaborate with world leaders in academia and industry, and regularly assist in providing advices to regulatory governmental agencies.