Designing, developing and validating advanced materials and surface modifications for innovative biomaterials and implants

在过去的几十年里，生物材料成功地改善了数百万人的生活质量。然而，生物材料和医疗器械完全成功的应用非常罕见。失败或临床并发症经常被观察到，不同的应用有不同的发生率。这一发现计划非常坚实地建立在先进的材料科学和工程方面应用于健康，特别是医疗领域的基础上。建议的长期愿景是深化和巩固一个新的三块研究计划：1)研究允许开发高附着力和强粘合涂层的参数，主要基于对金属设备的等离子体表面改性；2)设计一种新的专门用于临时设备的生物可吸收金属；以及3)开发新开发的涂层和金属植入人体后的生物性能测试、评估和预测的新策略。区块1和区块2的总体目标是在短期内(1至5年)提供新涂层和新材料，以改善医疗器械的临床性能。第三块的总体目标是在中期(5至10年)产生先进的(人类)体外细胞替代(动物)体内试验。这项研究具有极高的原创性和创新性，很可能在评估新开发的涂层和材料的命运和影响方面取得突破性进展，从组织再生的生理和病理3D培养的人类成年细胞血管壁模型。产生的原始科学知识肯定会改进风险评估，并支持政府机构制定监管指南。此外，拟议的研究计划旨在建立一个多价多面(涂层-材料-测试)平台，易于应用于其他领域和应用，这些领域和应用需要专门设计的材料和具有目标性能的涂层。在这项建议中，我们既提高了加拿大的关键实力领域的知识，又培训了高素质的人才。我们的研究环境是特殊的，特别适合于适应新的全球市场和我们今天面临的挑战。自2015年以来，超过100名HQP接受了培训：如今，他们利用与我们一起培训过的日常高级知识、领导力、快速适应技能、全球网络联系和战略思维，在学术界、行业和政府担任职务。总之，我们的实验室被公认为影响修复外科的临床和工业实践，在生物材料科学领域打开新的大门，为新发明申请专利和提出许可证，欢迎知名和年轻的科学家在国际会议上应邀演讲，与学术界和工业界的世界领袖密切合作，并定期协助向监管政府机构提供建议。

In the last decades, biomaterials have been successful to improve quality of the life for millions. However, very rare are the applications for which biomaterials and medical devices are completely successful. Failures or clinical complications are often observed, with different incidences related to the applications. This discovery program is very solidly based on advancing material science and engineering aspects applied to health, and in particular to the medical field. The proposed long-term vision is to deepen and consolidate a new 3 blocks-research program for: 1) investigating the parameters allowing the development of a highly-adherent and strongly-cohesive coating mainly based on plasma-based surface modification for metallic devices; 2) designing a new class of bioabsorbable metals specific for temporary devices; and 3) developing new strategies for testing, assessing and predicting the biological performances of the newly developed coatings and metals when implanted in humans. The overall goal of blocks 1 and 2 is to provide, at short term (1 to 5 years), new coatings and new materials to improve the clinical performances of medical devices. The overall goal of block 3 is to generate at medium term (5 to 10 years) advanced (human) cell-based in vitro alternative to (animal) in vivo tests. This research is extremely original and innovative and is likely to lead the ground-breaking advances in assessing the fate and impacts of newly-developed coatings and materials in a tissue-regenerated physio- and patho-logical 3D cultured vascular wall models from human adult cells. The original scientific knowledge generated is sure to improve risk assessments and support the development of regulatory guidelines by government agencies. Moreover, the proposed research program is planned to result in a polyvalent multi-facetted (coatings-materials-tests) platform susceptible to be applied to other fields and applications, where specifically-designed materials and coatings with targeted properties are required. In this proposal, we both advance knowledge and train high quality personnel in key areas of strength for Canada. Our research environment is exceptional and particularly adapted to meet the new Global market and challenges we are facing today. More than 100 HQP were trained since 2015: Today, they pursue positions in academia, industry and government by using daily advanced knowledge, leadership, fast adaptive skills, global network connections and strategic thinking for which they have been trained with us. In conclusion, our Laboratory is recognized to impact the clinical and industrial practice in reparative surgery, and to open new doors in Biomaterials Science, patent new inventions and propose licenses, welcome established and young scientists with invited lectures at international conferences, closely collaborate with world leaders in academia and industry, and regularly assist in providing advices to regulatory governmental agencies.