Phenotype analysis of cows originating from in vitro fertilization compared to artificial insemination

体外受精与人工授精奶牛的表型分析

• 批准号: 547639-2019
• 负责人: Sirard, MarcAndré
• 金额: $ 2.18万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=701215
• 关键词: Phenotype; analysis; cows; originating; vitro

The use of in vitro fertilization (IVF) is gradually increasing in the dairy genetics industry. A significant proportion of bulls and cows of high genetic value are now derived from IVF. There is currently no phenotypic monitoring of these animals although the fertility data, some health and productivity data are recorded by different stakeholders including Valacta. Therefore, there is no structured analysis to link the effects of IVF with the subsequent phenotype despite the amount of data available in bovine and published data in mice and humans. In these species, the phenotypic manifestations of IVF are strangely similar to the observed manifestations that are related to the metabolic status of the mother and therefore suggest that cattle may respond with metabolic programming useful for milk production. We will therefore match (genetic-environment) hundreds (>400) of animals from IVF and compare them to cows from artificial insemination for the parameters of productivity, fertility and longevity (health) from the last 8 years.This project will answer a very important question about the potential benefit or problems associated with the new reproductive technologies, allowing technical adjustments to maximse the value of these tools, and increasing our competitiveness in Quebec and for the export markets.

体外受精（IVF）在乳品遗传学行业的应用逐渐增加。现在，很大一部分具有高遗传价值的公牛和奶牛都是通过体外受精获得的。尽管包括 Valacta 在内的不同利益相关者记录了生育力数据、一些健康和生产力数据，但目前尚未对这些动物进行表型监测。因此，尽管有大量关于牛的数据以及已发表的小鼠和人类数据，但还没有结构化分析将体外受精的影响与随后的表型联系起来。在这些物种中，体外受精的表型表现与观察到的与母亲代谢状态相关的表现出奇地相似，因此表明牛可能会对产奶有用的代谢程序做出反应。因此，我们将匹配（遗传-环境）数百（> 400）只 IVF 动物，并将它们与人工授精的奶牛进行比较，以了解过去 8 年的生产力、生育力和寿命（健康）参数。该项目将回答一个非常重要的问题，即与新生殖技术相关的潜在益处或问题，允许进行技术调整，以最大限度地发挥这些工具的价值，并提高我们在魁北克的竞争力 以及出口市场。