Development of microneedle array patch for COVID-19 vaccine delivery
Development of microneedle array patch for COVID-19 vaccine delivery
批准号:
554916-2020
负责人:
Wu, XiaoYu
金额:
$3.64万
依托单位:
依托单位国家:
加拿大
项目类别:
Alliance Grants
财政年份:
2020
资助国家:
加拿大
项目状态:
已结题
起止时间:
2020-01-01 至 2021-12-31
中文摘要
新冠肺炎是一种全球性流行病,没有有效的治疗和预防药物。鉴于SARS-CoV-2的高传染性和疾病的严重性,迫切需要疫苗来应对这种新型冠状病毒的感染。到目前为止,在临床前测试和临床试验的不同阶段,正在探索各种类型的候选疫苗,包括基于RNA和DNA的疫苗、载体和减毒病毒以及重组蛋白。然而,也存在可能的不利影响和局限性。例如,基于RNA/DNA的疫苗可引发免疫反应,导致关键器官(如大脑和心脏)的有害后果,免疫原性低,免疫原半衰期短,载体传递效率低。为了克服这些问题,我们将与加拿大一家生物技术公司合作,开发用于输送多组分疫苗的微针阵列,以提高新冠肺炎的效力,同时增加疫苗接种的安全性。
英文摘要
COVID-19 is a global pandemic with no effective therapeutic and preventive agents. Given the high infectivity of the SARS-CoV-2 and severity of the disease, vaccines are urgently needed to tackle the infection of this novel coronavirus. Thus far, various types of vaccine candidates, in different stages of preclinical testing and clinical trials, are being explored, including RNA- and DNA-based, vectored and attenuated virus, and recombinant proteins. However, possible adverse effects and limitations exist. For example, RNA/DNA-based vaccines can trigger an immune response leading to detrimental consequences in key organs (e.g. brain and heart), low immunogenicity, short half-life of immunogen, and inefficient delivery of vectors. To overcome these problems, we will work with a Canadian biotechnology company to develop microneedle arrays for delivering multicomponent vaccine to boost the efficacy while increasing the safety of vaccination for COVID-19.
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批准号:RGPIN-2019-07204
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.4万
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财政年份:2022
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依托单位:
Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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批准号:RGPIN-2019-07204
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.4万
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负责人:Wu, XiaoYu
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依托单位:
Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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批准号:RGPIN-2019-07204
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.4万
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财政年份:2020
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负责人:Wu, XiaoYu
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依托单位:
Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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批准号:RGPIN-2019-07204
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.4万
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财政年份:2019
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负责人:Wu, XiaoYu
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Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.09万
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Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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资助金额:$2.55万
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负责人:Wu, XiaoYu
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依托单位:
Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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批准号:170460-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2014
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负责人:Wu, XiaoYu
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依托单位:
Multifunctional intelligent polymers and polymer-inorganic hybrid materials for biomedical applications
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批准号:170460-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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依托单位:
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负责人:Wu, XiaoYu
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依托单位:
Instrument for characterization of polymers and nanoparticles
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$6.55万
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财政年份:2012
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负责人:Wu, XiaoYu
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依托单位:
Molecular mechanism of polymer dynamics and kinetics of solute transport in multicomponent systems
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批准号:170460-2008
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.17万
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负责人:Wu, XiaoYu
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依托单位:
Kinetics and mechanism of solute transport in heterogeneous polymer systems
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.97万
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财政年份:2005
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负责人:Wu, XiaoYu
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依托单位:
Kinetics and mechanism of solute transport in heterogeneous polymer systems
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批准号:170460-2003
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.97万
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财政年份:2004
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负责人:Wu, XiaoYu
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依托单位:
Kinetics and mechanism of solute transport in heterogeneous polymer systems
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批准号:170460-2003
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.97万
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依托单位:
Solute diffusion in heterogenous polymeric matrices
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.04万
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负责人:Wu, XiaoYu
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依托单位:
Solute diffusion in heterogenous polymeric matrices
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批准号:170460-1999
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.04万
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负责人:Wu, XiaoYu
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依托单位:
Kinetics and mechanism of solute diffusion through polymeric matrices
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海外基金