Antioxidant-presenting, hard silicone-coated surfaces that kill COVID-19

具有抗氧化剂的硬质硅胶涂层表面可杀死 COVID-19

• 批准号: 554621-2020
• 负责人: Brook, Michael
• 金额: $ 3.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705698
• 关键词: Antioxidant; presenting; hard; silicone; coated

Viruses are susceptible to antioxidants. In addition, COVID-19 is particularly susceptible to surfactants, which is why we all wash our hands to kill the virus. We propose to combine these two vulnerabilities to make silicone coatings for surfaces (e.g., for use on hospital beds, doorknobs) to render them anti-viral. Silicone elastomers have a low surface energy, which will be combined with antioxidants: i) that are physically mixed; or, ii) chemically tethered into the matrix. The antioxidants will bloom to the interface and be released or, in the case of tethered antioxidants, will present at the interface. The resulting antioxidant surfaces will lead to COVID-19 death. The research project involves small molecule and polymer synthesis, physical characterization, and biological assessment using, initially, a safe virus bacteriophage as a surrogate for COVID-19. Eventually, in concert with collaborators in McMaster hospital, the surfaces will be tested with live virus. Our partner, Siltech, is a world leader in surface active silicones. They will scale up and test promising surface formlulations. 2 HQP will be involved in this process, a graduate student and 1/3 of a PDF.

病毒易受抗氧化剂的影响。 此外，COVID-19特别容易受到表面活性剂的影响，这就是为什么我们都要洗手来杀死病毒。我们建议联合收割机将这两个弱点结合起来，制造用于表面的有机硅涂层（例如，用于医院病床、门把手）以使它们抗病毒。有机硅弹性体具有低表面能，其将与抗氧化剂结合：i）物理混合;或ii）化学束缚到基质中。抗氧化剂将在界面上开花并被释放，或者在系留的抗氧化剂的情况下，将存在于界面处。 由此产生的抗氧化剂表面将导致COVID-19死亡。 该研究项目涉及小分子和聚合物合成，物理表征和生物评估，最初使用安全的病毒噬菌体作为COVID-19的替代品。最终，在麦克马斯特医院的合作者的配合下，这些表面将用活病毒进行测试。 我们的合作伙伴Siltech是表面活性有机硅的全球领导者。他们将扩大规模并测试有希望的表面配方。2名HQP将参与此过程，一名研究生和1/3的PDF。