Hydrogel Endovascular Adaptive BioExtrusion System (HEABES) as a new platform for endovascular treatment

水凝胶血管内自适应生物挤出系统（HEABES）作为血管内治疗的新平台

• 批准号: 556274-2020
• 负责人: Yang, Victor
• 金额: $ 9.11万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=706077
• 关键词: Hydrogel; Endovascular; Adaptive; BioExtrusion; System

We have engineered a new type of endovascular hydrogel delivery system. Our technology, Hydrogel Endovascular Adaptive BioExtrusion System (HEABES), is a catheter-based, multi-material (hydrogels and/or nutrients, bioactive factors, cells) co-extrusion device that can dynamically change physicochemical properties while maintaining high spatiotemporal delivery accuracy, suitable for drug delivery, tissue engineering, and embolization. In this project we aim to perform design refinement and testing to prove its efficacy bot in vitro and in vivo. This new technology represents a safer and more effective method of embolization, drug delivery and potential for minimally invasive tissue engineering approaches.

我们设计了一种新型的血管内水凝胶输送系统。我们的技术，水凝胶血管内自适应生物挤出系统（HEABES），是一种基于导管的多材料（水凝胶和/或营养素、生物活性因子、细胞）共挤出器械，可动态改变理化性质，同时保持高时空输送精度，适用于药物输送、组织工程和栓塞。在这个项目中，我们的目标是进行设计改进和测试，以证明其在体外和体内的功效。这项新技术代表了一种更安全，更有效的栓塞方法，药物输送和微创组织工程方法的潜力。