Design, developement and validation of materials and surfaces for innovative biomaterials

在过去的几十年里，生物材料已经成功地改善了数百万人的生活质量。然而，生物材料和医疗器械的应用非常罕见。经常观察到失效或临床并发症，其发生率与应用相关。我提出的研究建议是一个NSERC发现计划，非常坚实的基础和锚定研究材料科学和工程方面应用于心血管医学领域。 具体而言，我建议继续并巩固一个新的3块研究项目：1）研究主要基于金属器械等离子体聚合的高粘附性和强内聚性涂层开发参数; 2）设计一种新的心血管器械专用可降解金属;和3）开发在特定受控生物反应器中在机械应力下使材料和细胞界面化以再生血管组织的新策略。模块1和模块2的总体目标是在短期和中期（1 - 5年）内提供能够改善医疗器械临床性能的新涂层和新材料。模块3的总体目标是产生有针对性的知识和专业知识，以便产生长期（10至15年）的功能性血管组织再生的具体方法。 拟议的研究计划是非常中肯和及时的，以回答高素质人才的形成，从而满足精确的社会需求，医疗器械行业的挑战的需要。此外，拟议的研究计划计划将产生一个多价技术平台，该平台易于应用于其他领域和应用，包括制药，耐腐蚀，光学，家用，军事和工业，其中需要专门设计的材料和具有目标特性的涂层。我们使用先进的材料科学和工程技术为生物医学挑战提供工程解决方案。 在这个建议中，我们既推进知识，又在加拿大的关键优势领域培养高素质的人才。我们的研究环境是特殊的，特别是适应我们现在面临的新的全球市场时代。自2008年以来，超过100名HQP在我们的实验室接受了培训：今天，他们通过使用日常先进知识，领导力，快速适应技能，全球网络连接和战略思维来追求学术界，工业和政府的职位。我们的实验室被公认为在科学领域广泛出版和打开新的大门，为新发明申请专利和提出许可证，出席国际会议，与四大洲的学术界和工业界的二十多位世界领导者合作，并为政府监管机构提供建议。

In the last decades, biomaterials have been successful to improve quality of the life for millions. However, very rare are the applications for which biomaterials and medical devices are completely successful. Failures or clinical complications are often observed, with different incidences related to the applications. The Research Proposal I am putting forward is a NSERC discovery program very solidly based and anchored on studying material science and engineering aspects applied to the cardiovascular medical field. Specifically, I propose to pursue and consolidate a new 3 blocks-research program for: 1) investigating the parameters allowing the development of a highly-adherent and strongly-cohesive coating mainly based on plasma polymerization for metallic devices; 2) designing a new class of degradable metals specific for cardiovascular devices; and 3) developing new strategies for interfacing materials and cells under mechanical stresses in specific controlled bioreactors for the regeneration of the vascular tissue. The overall goal of blocks 1 and 2 is to provide at short and medium terms (1 to 5 years) new coatings and new materials capable to improve the clinical performances of medical devices. The overall goal of block 3 is to produce targeted knowledge and expertise susceptible to generate at long terms (10 to 15 years) specific methodologies for the regeneration of the functional vascular tissue. The proposed research program is very pertinent and timed to answer the need of the formation of highly qualified personnel, thus fulfilling precise social needs, and medical-device industry challenges. Moreover, the proposed research program is planned to result in a polyvalent technological platform susceptible to be applied to other fields and applications, including pharmaceutical, corrosion-resistant, optical, domestic, military and industrial, where specifically-designed materials and coatings with targeted properties are required. We are engineering solutions to biomedical challenges using advanced materials science and engineering. In this proposal, we both advance knowledge and train high quality personnel in key areas of strength for Canada. Our research environment is exceptional and particularly adapted to the new global market era we are facing now. More than 100 HQP were trained in our laboratory since 2008: Today, they pursue positions in academia, industry and government by using daily advanced knowledge, leadership, fast adaptive skills, global network connections and strategic thinking for which they have been trained with us. Our Laboratory is recognised to publish widely and in opening new doors in Science, patent new inventions and propose licenses, present at international conferences, collaborate with some twenty world leaders in academia and industry in four continents, and provide advices to regulatory governmental agencies.