Role of anterior olfactory nucleus for multi-sensory integration in the olfactory system
前嗅核在嗅觉系统多感觉整合中的作用
基本信息
- 批准号:10634755
- 负责人:
- 金额:$ 65.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AnimalsAnteriorAreaBehavioralBrainCollaborationsCuesDataDecision MakingElectrophysiology (science)ExhibitsFiberHippocampusImmediate-Early GenesIpsilateralLabelLearningMapsMeasurementMediatingMental HealthNeuronsOdorsOlfactory PathwaysPatientsPerceptionPhysiologicalPlayPost-Traumatic Stress DisordersPricePublishingResearchResearch PersonnelRodentRoleSensorySeriesSignal TransductionSmell PerceptionStimulusStructureSystemTestingTimeTraumaawakedesensitizationexperimental studyhippocampal pyramidal neuroninterestmaladaptive behaviormultimodalitymultisensoryneuralneural networkneurophysiologyolfactory bulbolfactory nucleioptogeneticspiriform cortexresponsesensory integrationspatial integrationtool
项目摘要
Project Summary
Sensory signals encountered under different circumstances may have quite different implications. In the
early olfactory system, preliminary evidence suggests that this (non-olfactory) contextual information is
integrated into odor representations at a very early stage, potentially even the main olfactory bulb. Recent
evidence indicates that the anterior olfactory nucleus (AON), a structure directly adjoining the olfactory bulb,
serves to integrate afferent odor information with contextual information from the ventral hippocampus
(vHC) and is necessary to solve contextually-dependent olfactory decision-making tasks.
The vHC is known to relay task-relevant spatial contextual information to other brain systems. We here
hypothesize that direct projections from the vHC to the AON play a dominant role in the integration of
contextual and olfactory information, and that the AON embeds this multisensory contextual information into
early-stage odor representations. Our preliminary data show that rodents can learn to respond differently to
odors based on the spatial context in which they are encountered, and that the expression of such a rule
depends on both AON and vHC, whereas a similar but odor-independent task requires vHC but not AON.
We propose a multipronged approach to understanding the integration of spatial context into olfactory
representations, engaging electrophysiological ensemble recordings and interareal coherence
measurements in awake, behaving rodents, the optogenetic manipulation of vHC and AON circuit activities,
and a double-labeling strategy for the within-subjects comparison of immediate-early gene (Fos) responses
across two experimental conditions separated in time.
项目概要
在不同情况下遇到的感官信号可能会产生截然不同的含义。在
早期嗅觉系统,初步证据表明这种(非嗅觉)上下文信息是
在很早的阶段就融入到气味表征中,甚至可能融入到主嗅球中。最近的
有证据表明前嗅核(AON)是直接毗邻嗅球的结构,
用于将传入的气味信息与来自腹侧海马的上下文信息整合起来
(vHC)并且对于解决上下文相关的嗅觉决策任务是必要的。
众所周知,vHC 会将与任务相关的空间上下文信息传递给其他大脑系统。我们在这里
假设从 vHC 到 AON 的直接投影在整合中起主导作用
上下文和嗅觉信息,并且 AON 将这种多感官上下文信息嵌入到
早期气味表征。我们的初步数据表明,啮齿类动物可以学会对以下情况做出不同的反应:
气味基于它们遇到的空间环境,并且这种规则的表达
取决于 AON 和 vHC,而类似但与气味无关的任务需要 vHC 而不是 AON。
我们提出了一种多管齐下的方法来理解空间背景与嗅觉的整合
表征、参与电生理学合奏记录和区域间一致性
清醒、行为啮齿类动物的测量、vHC 和 AON 电路活动的光遗传学操作,
以及用于受试者内立即早期基因(Fos)反应比较的双标记策略
跨越两个时间间隔的实验条件。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas A Cleland其他文献
Thomas A Cleland的其他文献
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{{ truncateString('Thomas A Cleland', 18)}}的其他基金
Role of anterior olfactory nucleus for multi-sensory integration in the olfactory system
前嗅核在嗅觉系统多感觉整合中的作用
- 批准号:
10589501 - 财政年份:2021
- 资助金额:
$ 65.06万 - 项目类别:
Role of anterior olfactory nucleus for multi-sensory integration in the olfactory system
前嗅核在嗅觉系统多感觉整合中的作用
- 批准号:
10295363 - 财政年份:2021
- 资助金额:
$ 65.06万 - 项目类别:
Circuit architecture and dynamics in odor representation and perception
气味表征和感知的电路架构和动力学
- 批准号:
10390573 - 财政年份:2015
- 资助金额:
$ 65.06万 - 项目类别:
Circuit architecture and dynamics in odor representation and perception
气味表征和感知的电路架构和动力学
- 批准号:
10613409 - 财政年份:2015
- 资助金额:
$ 65.06万 - 项目类别:
Circuit architecture and dynamics representation in odor perception
气味感知中的电路架构和动态表示
- 批准号:
9096828 - 财政年份:2015
- 资助金额:
$ 65.06万 - 项目类别:
CRCNS: Dynamical mechanisms of oscillation transitions in the olfactory system
CRCNS:嗅觉系统振荡转变的动力学机制
- 批准号:
9284443 - 财政年份:2014
- 资助金额:
$ 65.06万 - 项目类别:
CRCNS: Dynamical mechanisms of oscillation transitions in the olfactory system
CRCNS:嗅觉系统振荡转变的动力学机制
- 批准号:
8837265 - 财政年份:2014
- 资助金额:
$ 65.06万 - 项目类别:
CRCNS: Dynamical mechanisms of oscillation transitions in the olfactory system
CRCNS:嗅觉系统振荡转变的动力学机制
- 批准号:
8853266 - 财政年份:2014
- 资助金额:
$ 65.06万 - 项目类别:
CRCNS: Higher-order feature detection in olfactory bulb
CRCNS:嗅球中的高阶特征检测
- 批准号:
8523031 - 财政年份:2011
- 资助金额:
$ 65.06万 - 项目类别:
CRCNS: Higher-order feature detection in olfactory bulb
CRCNS:嗅球中的高阶特征检测
- 批准号:
8313859 - 财政年份:2011
- 资助金额:
$ 65.06万 - 项目类别:
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