Role of anterior olfactory nucleus for multi-sensory integration in the olfactory system

前嗅核在嗅觉系统多感觉整合中的作用

• 批准号: 10295363
• 负责人: Thomas A Cleland
• 金额: $ 65.16万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10295363
• 关键词: Animals; Anterior; Area; Behavior; Behavioral; Brain; Cues; Data; Decision Making; Electrophysiology (science); Exhibits; Fiber; Hippocampus (Brain); Immediate-Early Genes; Ipsilateral; Label; Lead; Learning; Measurement; Mediating; Mental Health; Neurons; Odors; Olfactory Pathways; Patients; Perception; Physiological; Play; Post-Traumatic Stress Disorders; Price; Publishing; Research; Research Personnel; Rodent; Role; Sensory; Series; Signal Transduction; Smell Perception; Stimulus; Structure; System; Testing; Time; Trauma; awake; base; desensitization; experimental study; hippocampal pyramidal neuron; interest; multimodality; multisensory; neural network; neurophysiology; olfactory bulb; olfactory nuclei; optogenetics; piriform cortex; relating to nervous system; response; spatial integration; tool

Project Summary Sensory signals encountered under different circumstances may have quite different implications. In the early olfactory system, preliminary evidence suggests that this (non-olfactory) contextual information is integrated into odor representations at a very early stage, potentially even the main olfactory bulb. Recent evidence indicates that the anterior olfactory nucleus (AON), a structure directly adjoining the olfactory bulb, serves to integrate afferent odor information with contextual information from the ventral hippocampus (vHC) and is necessary to solve contextually-dependent olfactory decision-making tasks. The vHC is known to relay task-relevant spatial contextual information to other brain systems. We here hypothesize that direct projections from the vHC to the AON play a dominant role in the integration of contextual and olfactory information, and that the AON embeds this multisensory contextual information into early-stage odor representations. Our preliminary data show that rodents can learn to respond differently to odors based on the spatial context in which they are encountered, and that the expression of such a rule depends on both AON and vHC, whereas a similar but odor-independent task requires vHC but not AON. We propose a multipronged approach to understanding the integration of spatial context into olfactory representations, engaging electrophysiological ensemble recordings and interareal coherence measurements in awake, behaving rodents, the optogenetic manipulation of vHC and AON circuit activities, and a double-labeling strategy for the within-subjects comparison of immediate-early gene (Fos) responses across two experimental conditions separated in time.

项目总结