Rational Integration of Molecular and surface interactions for lubricating, adhesive and high penetration soft materials

润滑、粘合和高渗透软材料的分子和表面相互作用的合理整合

• 批准号: RGPIN-2020-06778
• 负责人: Banquy, Xavier
• 金额: $ 2.84万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762030
• 关键词: Rational; Integration; Molecular; surface; interactions

Soft polymeric materials are widely used as drug delivery systems, adhesive or lubricants in industrial and everyday life devices. With the emergence of new technological fields such as soft microelectronics, wearable diagnostics or soft robotics, their use is expected to grow even more in the near future. Even though the properties of these materials have been improved over decades of development and optimization, the fundamental concepts used for their design has surprisingly not significantly evolved. This stagnancy has created a lack of knowledge that is hampering the translation of novel technologies where fast bonding/debonding, stimuli responsive lubrication or high tissue penetration are required. The technological challenge inherent to the development of such materials is the control of intermolecular forcesbetween the material and its environment. The aim of the present research program is to palliate to this lack of knowledge and to provide technological innovations by rationally integrating molecular and surface interactions into the design of novel soft materials. Our approach consists in using soft polymers exhibiting a unique architecture called bottle-brush (BB) and to integrate such polymers into stimuli responsive materials. The unique properties of BB polymers and their ability to interact in synergy with their environment enables the creation of novel technologies never explored before. Our research program explores three main areas: 1- Stimuli responsive lubricating systems 2-Stimuli responsive adhesives 3-Stimuli responsive nanodevices for deep tissue drug delivery These studies will build a unique ground of knowledge to advance the development of stimuli responsive BB polymers and validate their potential use in new technologies that are presently in high demand. We foresee that Canada's biotechnological industry will benefit the most from the different technological platforms that will be tested during this research program.

软质高分子材料在工业和日常生活设备中广泛用作药物输送系统、粘合剂或润滑剂。随着软微电子、可穿戴诊断或软机器人等新技术领域的出现，它们的使用预计将在不久的将来进一步增长。尽管经过几十年的发展和优化，这些材料的性能已经得到了改善，但令人惊讶的是，用于其设计的基本概念并没有显著的发展。这种停滞造成了知识的缺乏，阻碍了需要快速粘合/脱粘、刺激响应润滑或高组织渗透的新技术的转化。开发这种材料所固有的技术挑战是控制材料与其环境之间的分子间作用力。目前研究计划的目的是通过合理地将分子和表面相互作用整合到新型软材料的设计中，来缓解这种知识的缺乏，并提供技术创新。我们的方法包括使用具有独特结构的软聚合物，称为瓶刷（BB），并将这种聚合物集成到刺激响应材料中。BB聚合物的独特性质及其与环境协同作用的能力使其能够创造前所未有的新技术。我们的研究计划探索了三个主要领域：1-刺激反应润滑系统2-刺激反应粘合剂3-刺激反应纳米器件用于深层组织药物输送这些研究将建立一个独特的知识基础，以推进刺激反应BB聚合物的发展，并验证其在当前高需求的新技术中的潜在应用。我们预计加拿大的生物技术产业将从该研究项目中测试的不同技术平台中获益最多。