Functional polymer alloys as drug delivery vehicles

作为药物输送载体的功能聚合物合金

• 批准号: 518970-2017
• 负责人: Banquy, Xavier
• 金额: $ 1.81万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639653
• 关键词: Functional; polymer; alloys; drug; delivery

This research project explores the use of polymer alloys as drug delivery systems. Sustained long term deliveryof pharmaceutical compounds is and extremely challenging tasks and requires the development of complexdelivery systems. Such systems must be biocompatible, biodegradable and minimally invasive in order toperform over long period of time. The use of polymer alloys appears to be a straightforward solution to thistechnological problem. They offer unprecedent versatility in terms of control of erosion rate and activecompound release as well as unmatched biocompatibility profile. The proposed study will establish thefundamental properties of polymer alloys as drug delivery systems and will provide the industrial partner with astrong knowledge of their potential performances in biomedical devices such as implants.

本研究项目探讨了聚合物合金作为药物输送系统的用途。药物化合物的持续长期递送是一项极具挑战性的任务，需要开发复杂的递送系统。这样的系统必须是生物相容的，可生物降解的和微创的，以便长时间运行。聚合物合金的使用似乎是解决这一技术问题的一个简单的方法。它们在控制侵蚀速率和活性化合物释放以及无与伦比的生物相容性方面提供了前所未有的多功能性。拟议的研究将确立聚合物合金作为药物输送系统的基本特性，并将为工业合作伙伴提供有关其在生物医学设备（如植入物）中的潜在性能的强大知识。