Adhesion-based cell sorter

该提案旨在收购基于粘附的细胞分选仪，以支持我们在组织工程，生物传感和生物材料化学领域的研究工作。该仪器使用聚焦超声波来操纵细胞，并以高度并行化的方式定量测量它们与功能化基底的相互作用力，从而实现高通量和高统计功率。该工具将广泛用于目前在蒙特利尔大学和理工学院部署的四个研究重点，并由本提案中收集的PI领导。这些研究方向包括：1）开发用于超导电涂层的功能聚合物; 2）设计和表征用于下一代智能设备和响应微流体设备的响应/指导性纳米膜; 3）下一代医疗器械生物功能支架的合成和验证，4）用于探索细胞表面相互作用的电活性基质的开发 * 在仪器上的收购将提供高素质的人员在生物材料粘附和与生物物质的相互作用的独特专业知识。该仪器的独特功能使其对本提案中包括的六名研究人员领导的不同多学科研究计划产生了强烈的影响。

This proposal seeks the acquisition of an adhesion-based cell sorter to support our research efforts in the fields of tissue engineering, biosensing and biomaterials chemistry. The instrument uses focused ultrasound waves to manipulate cells and measure quantitatively their interaction forces with a functionalized substrate in a highly parallelized fashion guarantying high throughput and high statistical power. The instrument will be extensively utilized in four research thrusts that are currently deployed across the University of Montreal and Ecole Polytechnique and lead by the PIs gathered in this proposal.***These research thrusts include 1) the development of functional polymers for super-antifouling coatings; 2) the design and characterization of responsive/instructive nanofilms for next generation smart devices and responsive microfluidic devices; 3) the synthesis and validation of Biofunctional scaffolds for next generation medical devices and 4) the development of electroactive substrates for the exploration of cell-surface interactions ***Acquisition on the instrument will provide highly qualified personnel with a unique expertise in biomaterial adhesion and interaction with living matter. The unique capabilities of the instrument guaranties its strong impact on the different multidisciplinary research programs led by the six investigators included in this proposal.**