Adhesion-based cell sorter

这项提案寻求收购一种基于黏附的细胞分选器，以支持我们在组织工程、生物传感和生物材料化学领域的研究努力。该仪器使用聚焦的超声波来操纵细胞，并以高度并行的方式定量测量它们与功能化衬底的相互作用力，从而确保高吞吐量和高统计能力。该仪器将被广泛用于目前部署在蒙特利尔大学和巴黎高等理工学院的四个研究项目中，并由本提案中收集的PI牵头。*这些研究项目包括1)开发用于超级防污涂料的功能聚合物；2)用于下一代智能设备和响应微流体设备的响应性/指导性纳米膜的设计和表征；3)下一代医疗设备的生物功能支架的合成和验证；4)开发用于探索细胞-表面相互作用的电活性衬底*该仪器的获取将为高素质的人员提供材料粘合和与生物物质相互作用方面的独特专业知识。该仪器的独特能力保证了它对本提案中包括的六名研究人员领导的不同多学科研究计划的强大影响。**

This proposal seeks the acquisition of an adhesion-based cell sorter to support our research efforts in the fields of tissue engineering, biosensing and biomaterials chemistry. The instrument uses focused ultrasound waves to manipulate cells and measure quantitatively their interaction forces with a functionalized substrate in a highly parallelized fashion guarantying high throughput and high statistical power. The instrument will be extensively utilized in four research thrusts that are currently deployed across the University of Montreal and Ecole Polytechnique and lead by the PIs gathered in this proposal.***These research thrusts include 1) the development of functional polymers for super-antifouling coatings; 2) the design and characterization of responsive/instructive nanofilms for next generation smart devices and responsive microfluidic devices; 3) the synthesis and validation of Biofunctional scaffolds for next generation medical devices and 4) the development of electroactive substrates for the exploration of cell-surface interactions ***Acquisition on the instrument will provide highly qualified personnel with a unique expertise in biomaterial adhesion and interaction with living matter. The unique capabilities of the instrument guaranties its strong impact on the different multidisciplinary research programs led by the six investigators included in this proposal.**