New Functional Polymers for Next Generation Contact Lenses - a Phase I Project

用于下一代隐形眼镜的新型功能聚合物——一期项目

• 批准号: 538495-2019
• 负责人: Banquy, Xavier
• 金额: $ 8.71万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693049
• 关键词: New; Functional; Polymers; Next; Generation

This proposal aims to develop a novel technology for producing the next generation of hydrogel-based contact lenses. Current contact lenses products suffer from different drawbacks such as extensive lachrymal proteins deposition, poor lubrication or low hydration retention which creates discomfort and eye irritation. Current technologies have been focused on one or two of these issues but never on all three simultaneously. We propose the incorporate in the hydrogel network forming the lens a polymer that has the unique attribute of being superlubricant and super antifouling agent and highly hydrated. The combination of these properties in a single polymer allows to formulate hydrogel networks that present very strong resistance to protein adsorption and high water retention over long period of time and superlubrication properties. This phase I project will evaluate the toxicity of the polymer additive on model corneal tissues, its stability during sterilization and finally its residence time in the lens. These results will allow us to convince industrial partners who have manifested their interest in the present technology to further support its translation of this technology into a commercial product.

这项提议旨在开发一种生产下一代水凝胶隐形眼镜的新技术。目前的隐形眼镜产品存在着不同的缺点，如泪液蛋白沉积广泛，润滑性差，或水合保持率低，造成不适和眼睛刺激。目前的技术一直专注于其中的一到两个问题，但从未同时关注这三个问题。我们建议在形成透镜的水凝胶网络中加入一种具有超级润滑剂和超级防污剂的独特属性的高度水合的聚合物。将这些特性结合在一种聚合物中，可以形成水凝胶网络，具有非常强的抗蛋白质吸附能力、长时间的高保水性和超润滑性。这个第一阶段的项目将评估聚合物添加剂对模型角膜组织的毒性，它在灭菌过程中的稳定性，最后它在晶状体中的停留时间。这些结果将使我们能够说服对目前技术表现出兴趣的工业合作伙伴进一步支持其将这项技术转化为商业产品。