New Functional Polymers for Next Generation Contact Lenses - a Phase I Project

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This proposal aims to develop a novel technology for producing the next generation of hydrogel-based contact lenses. Current contact lenses products suffer from different drawbacks such as extensive lachrymal proteins deposition, poor lubrication or low hydration retention which creates discomfort and eye irritation. Current technologies have been focused on one or two of these issues but never on all three simultaneously. We propose the incorporate in the hydrogel network forming the lens a polymer that has the unique attribute of being superlubricant and super antifouling agent and highly hydrated. The combination of these properties in a single polymer allows to formulate hydrogel networks that present very strong resistance to protein adsorption and high water retention over long period of time and superlubrication properties. This phase I project will evaluate the toxicity of the polymer additive on model corneal tissues, its stability during sterilization and finally its residence time in the lens. These results will allow us to convince industrial partners who have manifested their interest in the present technology to further support its translation of this technology into a commercial product.