Brain-Heart Interconnectome

大脑/精神系统疾病（例如，神经变性、脑血管、精神健康状况）和心血管系统（例如，冠状动脉疾病、心力衰竭、心房纤颤）在全球疾病负担和死亡率中所占份额超过所有其他疾病。 在加拿大，仅心脏病、中风和痴呆症的经济负担就超过每年550亿美元，这些疾病的持续增加将超过我们的医疗预算（每年医疗费用超过200亿美元）。 事实上，脑-心（B-H）疾病一直是造成与流行病相关的过度负担的主要因素，这使加拿大的医疗保健系统陷入危机。大脑和心脏在健康和疾病方面有着深刻的联系。 在疾病背景下，它们是相互的风险因素，它们经常同时出现，与特别差的结果有关，并因生物命运和社会不平等而放大。 然而，B-H疾病目前在诊断、治疗、预防和研究方面都是孤立的。脑-心互连组（BHI）将是第一个专门研究、预防和治疗共同发生的B-H疾病的跨学科研究计划。 我们将提供：1）用于早期诊断、风险预测和干预的生物标志物和成像工具。2）用于治疗B-H疾病共发的生物药物干预。3）用于治疗、预防和建立依从性的生活方式、非药物和文化干预。4）针对边缘化、土著和种族高风险社区的预防和治疗策略。5）在学习型卫生系统中，以患者为主导的转型护理模式。我们将培养互联组科学和脑心整合领域的第一代研究领导者，引领新型综合知识转化和嵌入EDI的研究方法。 BHI将因其脑心协作门户网站而获得全球认可，为卫生专业人员和患者提供大数据协作、最新信息和工具。 BHI将uOttawa、麦吉尔和uSaskatchewan的长期优先领域和卓越领域结合起来。在CFREF的资助下，BHI将与超过48个政府，非政府组织，私营部门和学术合作伙伴合作，并领导全球知名的B-H疾病范式转变，改善加拿大人的健康和生活质量，同时使加拿大经济和全球地位受益。

Diseases of the brain/mind system (e.g., neurodegenerative, cerebrovascular, mental health conditions) and the cardiovascular system (e.g., coronary disease, heart failure, atrial fibrillation), exceeds all other in the share of disease burden and mortality worldwide. In Canada, the economic burden of heart disease, stroke and dementia alone is >$55billion per year with the continued rise in these conditions set to overwhelm our healthcare budget (>$20B in annual healthcare costs). Indeed, brain-heart (B-H) conditions have been a major contributing factor to the pandemic-related excess burden that has brought Canada's healthcare system to a crisis point.The brain and heart are profoundly interlinked in health and disease. In the disease setting, they are mutual risk factors with their frequent co-occurrence associated with particularly poor outcomes, magnified by the biological fate and social inequities. Yet B-H diseases are currently siloed in diagnosis, treatment, prevention, and research.The Brain-Heart Interconnectome (BHI) will be the first dedicated interdisciplinary research program to study, prevent and treat co-occurring B-H disorders. We will deliver:1) Biomarker and imaging tools for early diagnosis, risk prediction and intervention.2) Biopharmaceutical interventions to treat B-H disease co-occurrence.3) Lifestyle, non-pharmaceutical and cultural interventions to treat, prevent and build resilience.4) Prevention and treatment strategies targeted to marginalized, Indigenous and ethnic high-risk communities.5) Transformational patient-led care models in a learning health system.We will train the first generation of research leaders in interconnectome science and brain-heart integration, leading the way with novel integrated knowledge translation and EDI-embedded approaches to research. The BHI will be recognized globally for the Brain-Heart Collaborative Portal, facilitating big data collaboration, up to date information and tools for health professionals and patients. These contribute to a Canada-first Brain-Heart Health Action Plan.BHI unites long-standing areas of priority and excellence from uOttawa, McGill and uSaskatchewan. With CFREF funding, BHI will engage more than 48 government, NGO, private sector and academic partners, and lead a globally-renowned paradigm shift for B-H diseases, improving the health and quality of life of Canadians, while benefiting the Canadian economy and global standing.