Improvement of electrodialytic processes performances for biofood applications using innovative electric current conditions

使用创新电流条件改善生物食品应用的电渗析工艺性能

• 批准号: RGPIN-2018-04128
• 负责人: Bazinet, Laurent
• 金额: $ 6.85万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=765360
• 关键词: Improvement; electrodialytic; processes; performances; biofood

Despite strong potential applications in the food, biopharmaceutical and biotechnology industries, a common problem with electrodialytic processes is membrane fouling. The most problematic ion-exchange membrane (IEM) fouling issues are scaling and fouling by peptides and proteins. Therefore, our research program seeks to understand how membrane characteristics and current mode conditions influence fouling and migration of food matrix components, as well as electroconvective vortex formation when biofood matrices undergo electrodialysis. The hypothesis of this research project is that the current mode (continuous current, reverse polarity (RP) and pulsed electric field (PEF)), current regime (underlimiting, limiting and overlimiting), current mode parameters (pulse/pause combinations, RP duration) and physicochemical characteristics of the membranes (nanopore size and distribution, hydrophilicity/hydrophobicity, ion-exchange capacity) affect the transport of food matrix components (mineral, peptides and proteins), their potential interactions with membranes and the resulting bioactivities of peptide fractions after application of electrodialytic processes. We defined three specific objectives for the proposed 5-year research program to answer this hypothesis according to the most problematic fouling type(s) related to each electrodialytic process: 1) To study the effects of the physicochemical characteristics of IEMs and PEF conditions on the formation of electroconvective vortices and IEM fouling mechanisms by food matrix components (mineral and peptides) during conventional electrodialysis (ED); 2) To study the impact of current modes and parameters on peptide fouling, migration selectivity, recovery yields and resulting bioactivities during electrodialysis with filtration membranes and 3) To understand the impact of PEF parameters on the prevention of mineral and protein fouling of membranes during electrodialysis with bipolar membranes.This research program will allow a better understanding of the relationships between food matrix components/nature of potential fouling, membrane characteristics/fouling prevention and current modes/fouling mitigation, as well as help to prevent membrane fouling in future and existing applications. It will also provide pertinent information about scaling up electrodialytic processes in terms of fouling prevention, and will highlight new areas of research and applications of the technology in the field of functional food and nutraceuticals. This research program will lead to a major breakthrough in scientific knowledge and research, not only for Canadian industries but also internationally and will be a unique opportunity to train needed highly qualified personnel.

尽管在食品、生物制药和生物技术工业中具有强大的潜在应用，但电渗析过程的常见问题是膜污染。最成问题的离子交换膜（IEM）结垢问题是由肽和蛋白质引起的结垢和结垢。因此，我们的研究计划旨在了解膜特性和电流模式条件如何影响食品基质成分的污染和迁移，以及生物食品基质进行电渗析时的电对流涡流形成。本研究项目的假设是，（连续电流、反极性（RP）和脉冲电场（PEF）），电流状态（欠限、限、过限），电流模式参数（脉冲/暂停组合，RP持续时间）和膜的理化特性（纳米孔的大小和分布、亲水性/疏水性、离子交换能力）影响食物基质成分的运输（矿物质、肽和蛋白质）、它们与膜的潜在相互作用以及应用电渗析过程后肽级分的所得生物活性。根据每种电渗析过程中最易产生污染的类型，我们为拟议的5年研究计划确定了三个具体目标来回答这一假设：1）研究IEM的物理化学特性和PEF条件对食品基质成分形成电对流涡旋和IEM污染机制的影响（矿物质和肽）在常规电渗析（艾德）期间; 2）研究电流模式和参数对肽污染、迁移选择性、在用过滤膜进行电渗析的过程中的回收率和所产生的生物活性，以及3）了解PEF参数对双极膜电渗析过程中防止膜中矿物质和蛋白质污染的影响。本研究项目将有助于更好地了解食品基质成分/潜在污染性质之间的关系，膜特性/污染预防和当前模式/污染减轻，以及有助于在未来和现有应用中防止膜污染。它还将提供有关在防污方面扩大电渗析工艺的相关信息，并将突出功能食品和营养品领域技术的新研究和应用领域。这项研究计划将导致科学知识和研究的重大突破，不仅对加拿大的工业，而且在国际上，将是一个独特的机会，培养所需的高素质人才。