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Preclinical development of highly potent and orally bioavailable PCSK9 inhibitors for patients at high cardiovascular risk

Preclinical development of highly potent and orally bioavailable PCSK9 inhibitors for patients at high cardiovascular risk
针对高心血管风险患者的高效口服 PCSK9 抑制剂的临床前开发
批准号:
494266
负责人:
Mayer Gatan
金额:
$7.29万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
已结题
起止时间:
2023-09-01 至 2024-09-01

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中文摘要
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英文摘要
Blood level of bad cholesterol is directly correlated with the incidence of atherosclerosis and cardiovascular risk. Statins, currently the most prescribed drugs to reduce blood cholesterol, works by increasing a cholesterol receptor in the liver. About 4
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会议论文
Function of PCSK9 in LDLR and CD36 degradation: LDL cholesterol regulation and beyond.
  • 批准号:
    293225
  • 项目类别:
    Operating Grants
  • 资助金额:
    $38.21万
  • 财政年份:
    2013
  • 负责人:
    Mayer Gatan
  • 依托单位:
The PCSK9-induced degradation of cell surface receptors: LDL cholesterol regulation and beyond.
  • 批准号:
    274738
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2012
  • 负责人:
    Mayer Gatan
  • 依托单位:
Molecular characterization and inhibition of the PCSK9-assisted low-density lipoprotein receptor degradation pathway.
  • 批准号:
    231136
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2011
  • 负责人:
    Mayer Gatan
  • 依托单位:
Molecular characterization and inhibition of the PCSK9-assisted low-density lipoprotein receptor degradation pathway.
  • 批准号:
    215523
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2010
  • 负责人:
    Mayer Gatan
  • 依托单位:
海外基金