脯氨酸修饰的多酸分子催化剂的制备与催化应用

多金属氧酸盐（POMs）催化剂在酸催化和氧化催化领域具有重要的应用价值。脯氨酸及其衍生物等手性有机小分子催化剂，具有结构简单、来源丰富和选择性高等优点，但存在催化剂用量大、难以回收和无法循环利用等不足。将脯氨酸的不对称催化、生物活性等功能特性引入到多酸，有望提升催化剂的不对称催化性能，简化催化剂与产物的分离过程，实现催化剂的便利回收与循环使用。本项目依据分子催化剂的设计思路，选用脯氨酸及其衍生物作为前驱体，通过共价键联的方式，设计合成一系列结构明确的脯氨酸及其衍生物共价修饰的Anderson和Lindqvist型多酸分子催化剂，探索手性多酸分子催化剂的合成规律，探究其催化性能及其合成应用。本项目将拓展多酸的研究领域，促进多酸在催化和有机合成领域中的应用，推动多酸化学的发展。

Polyoxometalates (POMs) have important applications in the field of acid catalysis and oxidation catalysis. Proline and its derivatives as a class of chiral organic small-molecule catalysts, have the advantages of simple structure, abundant source and high selectivity, but still have some disadvantages including large loading of catalyst, difficult to separate, recycle and reuse. The combination of POMs with proline and its derivatives may produce catalytic activities superior to its bulk. Meanwhile, the asymmetric catalysis and biological activities of proline can be transferred onto POMs. In addition, the POMs-proline hybrid catalysts can simplify the separation process of products from the catalysts and facilitate the recovery and recycling of catalysts. Based on the idea of organic small-molecule catalysts, we will design and synthesize a series of molecular catalysts of proline- derivatized Anderson and Lindqvist POMs with well-defined structure by covalently bonding with proline and its derivatives as the precursors, explore the law of synthesis of the POM-based chiral molecluar catalysts, their catalytic performance and potential application in organic synthesis. This project will expand the research field of POMs and promote the applications of POMs in catalysis and organic synthesis, and would push the development of POM chemistry.