采用磁共振技术研究帕金森病不同临床亚型患者的大脑差异

各种证据表明，帕金森病（PD）不是一种同质化的疾病，可以细分为不同的临床亚型。尽管磁共振已经成为研究PD大脑的重要手段，但是，绝大多数研究者没有意识到或者忽略了PD亚型之间的不同，以及由此可能对研究结果造成的影响。最近的功能磁共振研究发现，不同亚型PD患者大脑皮层和基底节之间的功能环路存在不同。在前期研究中我们发现，除了功能环路以外，不同亚型PD患者的大脑纤维束结构也存在显著差异，这种纤维束结构差异可能是功能环路不同的结构基础。本项目将在此基础上，运用先进的磁共振技术，全面分析不同亚型PD大脑的结构、功能、脑血流和脑铁含量及分布，了解PD各亚型大脑的功能差别，分析和寻找可能的结构和代谢基础，掌握各PD亚型的磁共振影像学特征以及变化规律，旨在为PD的临床分型提供磁共振影像学依据和标准，进一步丰富我们对不同PD亚型特征的认识，为深入研究PD的病变机制提供新的线索。

Many kinds of evidence suggested that Parkinson's disease (PD) is not a homogeneous disease, and can be subdivided into different clinical subtypes. Although magnetic resonance imaging has become an important tool to study the brain of PD patients, but the vast majority of investigators did not aware of or ignore the difference between PD subtypes, as well as the possible impact on results of those studies. Recently, several functional magnetic resonance imaging studies found that the functional loops between brain cortex and the basal ganglia were different between PD subtypes. We found in our previous study that, in addition to the functional loop, the structure of white matter fiber bundle was also different between PD subtypes. Furthermore, the difference in the white matter fiber bundle may underlie the difference in the functional loop in the brain of PD subtypes. On this basis, this project will use state-of-the-art magnetic resonance technology to analysis the brain function, structure, cerebral blood flow and brain iron content of the brain from different subtypes of PD patients. The purpose of this project is to detect the difference in brain function and find possible structural or metabolic basis between PD subtypes, to clarify the characteristics of different PD subtypes in magnetic resonance imaging, and to establish the imaging criterion of PD classification. The result of this project will enrich our understanding of the characteristics of different PD subtypes and provide new clues for the study of pathogenic mechanism of PD.