复杂天然产物的合成研究是有机化学的重要的方向之一，也是推动有机化学学科发展的重要动力之一。复杂天然产物还是药物研究最有效的先导化合物来源。研究天然产物合成对培养有机合成高级人才也有着无法替代的作用。本课题拟对若干含有多个含氧手性中心的特别是含有大环内酯的天然产物进行对映体选择性全合成以及相关的合成方法学研究。

Total synthesis of complex natural products represents one of the most important areas in organic chemistry. The studies along this line have also been a major driving force for the development of organic chemistry, the most important source for the drug leads, and an unreplaceable means for training advanced organic synthesis professionals. In this project, several complex natural products that contain multistereogenic centers enriched with oxygenated stereogenic centers will be chosen as the targets for study. En route to the total synthesis of the selected targets, new strategies and approaches are also to be developed.