选择“独参汤”为研究载体，基于国际上药物吸收、分布、代谢、排泄、毒性(ADMET)评价的新策略，创新性地发展基于ADMET/Act.（活性）性质一体化的中药效应物质的发现策略。根据中药主要以口服给药为主和多成分复杂体系的特点，综合多成分的体内过程，建立科学的生物利用度综合评价体系，走出中药生物利用度低的误区。结合生物学效应和临床应用的发现，建立确定真正的药效物质（效应成分）基础或效应物质组合物的技术方法，在系统性科学研究的基础上，确立相应的标准。打破国际技术壁垒，将国际公认、先进的模型与中药的实际相结合，有机地引入到中药物质基础系统研究中。以“独参汤”与肠内菌丛（生态环境）和可吸收成分与肝微粒体药物代谢酶亚型相互作用的稳定性、靶向分布、消除和生物学效应机制研究为模式，系统集成，循证“独参汤”口服应用的科学性，为中药物质基础研究提供新的思路和方法学，为科学制定中药质量标准提供示范性研究模式。

Using “Dushen decoction” as a vehicle, based on the new strategy of the evaluation of absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs, to innovatively develop the discovery strategy of the effect substances of Chinese materia medica (CMM) based on the integration of ADMET/Act. According to the CMM characteristics of mainly oral administration as well as a complex system of multi-composition, integrating the processes of metabolism and disposition in intra-body of multi-composition, to establish a scientific comprehensive evaluation system of bioavailability, out of the misunderstanding of low bioavailability of CMM. Combining findings on biological effects and clinical applications, to establish a technical method for determining true active material basis (active components) or active substance combinations and to establish corresponding standards on the basis of systematic research. Breaking international technical barriers, to combine internationally recognized and advanced models with the reality of CMM to introduce into the systematic study of CMM material basis. To probe into evidence-based scientificalness of oral administration of “Dushen decoction” from the system integration on the studies of the interactions between “Dushen decoction” and intestinal flora (ecotope) and between absorbant constituents and the drug metabolism enzyme subtypes of liver microsomes, targeting distribution, elimination, and biological effect mechanisms to give new ideas and methodologies for the study of material basis of CMM and to provide a exemplary model for the scientific development of the quality specification of CMM.