运动通过调控肠道微生物及其代谢物改善心肌梗死后病理性心室重构

心肌梗死（心梗）后的病理性心室重构最终将发展为心力衰竭。运动能有效防治心梗，保护心功能。肠道菌群与心血管疾病密切相关，但是肠道菌群在运动改善心梗后心室重构中的作用及机制尚不清楚。我们通过前期研究发现，小鼠心梗后进行跑步训练可以减轻心室重构，肠道菌群是运动发挥保护效应的重要因素，运动能够逆转心梗后菌群结构和种属丰度的改变。这初步提示，运动可能通过调节肠道菌群，改善心梗后的心室重构。在本项目中，我们将基于心梗小鼠运动、菌群剔除、粪菌移植这三个模型，开展肠道菌群的获得性和缺失性实验，明确肠道菌群和运动改善心梗后心室重构的关系。其次，将基于代谢组与微生物多样性关联分析，开展菌种移植和代谢物治疗，揭示肠道菌群及其代谢物在运动改善心梗后心室重构中的作用机制。综上，运动调控肠道菌群将有望成为改善心梗后病理性心室重构的新策略。

Pathological cardiac remodeling post myocardial infarction (MI) will ultimately develop to heart failure. Exercise is effective to protect against myocardial infarction and preserve cardiac function. Gut microbiota is closely related to cardiovascular diseases, however, the role of gut microbiota in exercise-induced protection for pathological cardiac remodeling after MI is still unclear. Our preliminary study found that exercise could attenuate pathological cardiac remodeling after MI,and gut microbiota may be essentially involved in this process. Moreover, exercise could restore the structure and abundance of gut microbiota upon MI. These data preliminarily suggest that exercise may prevent cardiac remodeling after MI through regulating gut microbiota. In this project, based on the running model of MI mice, gut microbiota removal, and faecal microbiota transplantation (FMT) models, we will perform gain- and loss- of function experiments to clarify the role of gut microbiota in exercise-induced protection for pathologic cardiac remodeling after MI. Then, based on correlation analysis between metabolome and microbiota diversity, we will perform microbiota transplantation and metabolites feeding experiments to clarify the mechanism of gut microbiota and metabolites in exercise-induced protection for pathologic cardiac remodeling after MI. Collectively, exercise-regulated gut microbiota might serve as a novel strategy to protect against pathologic cardiac remodeling after MI.