芳烃的高选择性碳氢键活化

苯及其衍生物结构片段广泛存在于自然界和生物体内，在功能材料、生物、医药、农药和化学等领域有着广泛的应用。C-H键活化具有很高的步骤经济性和原子经济性,符合现代绿色化学的发展方向, 被誉为是“化学的圣杯”，也是当前的前沿热点领域。苯、甲苯、苯酚等芳烃化合物廉价易得，同时来源非常丰富，因此发展新型的催化反应来实现芳烃的选择性C-H键活化，从而定向转化为高附加值化学品不仅在基础研究领域有重要的意义，也对国民生产提供了有力的技术支持。我们拟进行催化剂设计，利用金属催化的方式，实现芳烃C-H键活化的选择性；同时使用手性配体或手性催化剂，实现该类反应的不对称催化；利用这类反应，实现药物分子和功能材料分子的合成。

Substituted benzenes are ubiquitous motifs in nature, themedicinal chemistry and the materials-related fields. C-H bond functionalization, which is step economic and atom economic, is called “Holy Grail” and the most important subject in chemistry. Arenes, such as benzene, toluene and phenols etc. are abundant in the world. So the development of novel catalytic reaction to realize the selective C-H bond functionalization of arenes and convert them to high valued chemicals is important not only for basic science but also for national product. We want to develop novel metal-catalysts to achieve highly selective C-H bond functionalization of arenes. In addition, we also want to achieve the asymmetric catalysis of these reactions via chiral ligands and chiral catalysts. Finally, we want to synthesize drugs and material molecules via this approach.