金催化苯酚与重氮化合物的选择性反应

苯酚结构片段广泛存在于自然界和生物体内，是天然产物、药物分子以及功能材料分子的重要组成部分，实现高选择性的C-H键官能化对于有机合成以及药物分子的修饰都具有很重要的意义。重氮化合物是一种常用的C-H键官能化试剂，但是文献已知的重氮化合物与苯酚等化合物的反应都是发生在O-H键上。在前期的工作中，我们成功的实现了重氮化合物对苯酚的高选择性对位的C-H键官能化反应。在本项目中，结合我们在前期工作的基础，我们希望利用配体的调控来实现重氮化合物对苯酚邻位及间位的选择性C-H键官能化；同时，我们也希望利用这一系列C-H键官能化反应设计串联反应来构建一系列有用的分子砌块；另外，我们也希望利用手性配体来实现这一系列反应的不对称催化；最后，我们希望可以将这些反应应用到手性配体的合成，以及天然产物和药物分子的合成及修饰上。

Phenols are abundant in natural products and pharmaceutical agents and are valuable synthons in organic synthesis. Direct C-H functionalization of unprotected phenols is considered to be the important apporch to synthesis and modify these compouds. Diazocompounds are useful reagents for C-H functionalization. So far, the reaction of diazocompounds and phenols was O-H insertion. In our prvious work, we realized the highly selective para-C-H functionalization of phenols with diazo compoounds. In this project, based on our prior work, we want to realize the selective orth and meta C-H functionalization of phenols tuned by ligands. We also want to develop a series of cascade reactions based on C-H functionalization of phenols to access biulding blocks in natural products. Moreover, the asymmetric version of these reactions will be developed in our plan. Finally, these methodologies will be used in synthesis and modifications of chiral ligands, natural products and pharmaceutical agents.