新型手性膦多功能催化剂设计、合成及其在不对称催化中的应用

手性化合物在医药、香料、食品添加剂、农药、手性材料等许多方面应用非常广泛，而不对称催化是获取手性化合物最高效和应用前景的技术，因此是当前研究的热点。手性催化剂的设计与制备是不对称催化研究的核心内容，由于手性膦既可以做金属配体也可以用作有机小分子催化剂，因此受到广泛关注。在现有的手性膦催化剂中，β-胺基膦衍生物结构是一类优势骨架，在许多有机反应中都取得了很好的结果。但是，由于这类结构源于氨基酸及其衍生物，存在构型单一、取代基调控空间小等缺点，因此发展非天然氨基酸手性源的方法是非常必要的。在本项目中，结合我们前期的工作基础，我们拟发展一系列以手性亚磺酰胺为手性源的新型手性膦多功能催化剂。这一类催化剂具备两种构型、取代基变化的空间很大，同时手性源廉价易得（2200元/公斤）、合成路线简单。最后，我们希望能够将这一类催化剂应用到已知的膦催化剂无法实现的反应中，开发一系列膦催化的新型有机转化。

Much attention has been continuously paid to the development of asymmetric catalysis to obtain chiral compounds which are widely existed in pharmaceutical, fragrance, chiral materials and so on. The design and synthesis of chiral catalysts is the key issue in this field. Chiral phosphines have attracted much attention, because they are potentially useful as organocatalysts and ligands in metal-catalyzed reactions. β-aminophosphines as a class of valuable bi- or multi-functional catalysts have been found to be highly efficient for a variety of useful asymmetric transformations. The β-aminophosphines was normally accessible from commercially available a-amino acid, which underwent the limitation of substituents and unchangable chiral center. Thus, methods that do not rely on natural amino acids as basic chiral backbones have become highly desirable. Based on our previous work, we have developed a kind of chiral phosphine multifunctional catalys from cheap chiral sulfinamide, which showed great potential utility in the synthesis of various β-aminophosphines. Finally, we want to develop novel asymmetric organic transformation which can not realized using known phosphine catalysts.