衣霉素Tunicamycin是一类从细菌Streptomyces lysosuperficus的发酵物中分离得到的核苷糖缀类抗生素，由氨基葡萄糖、氨基半乳糖、尿苷以及脂肪边链四部分构成。这种与糖基转移酶给体相似的独特结构，使其具有罕见的能够抑制糖基转移酶的特性，是一类重要的研究糖基转移酶功能的分子工具。本项目将应用本课题组发展的新型一价金催化糖苷化方法，发展一条简洁高效的路线来完成衣霉素的全合成，并实现结构多样性的系列类似物的合成。为后续的构效关系和生物探针研究打下基础。

Tunicamycin, isolated from the fermentation of Streptomyces lysosuperficus, constitutes a unique family of antibiotics, which consist of glucosamine, galactosamine, uracil and aliphatic chain. Due to the structural similarity of tunicamycin to that of the glycosyltransferase donor, this type of compounds shows potent inhibitory activities against glycosyltransferase and has been widely used as tools in the studies on the function of glycosyltransferase. In this project, we aim to develop an efficient and concise approach to the total synthesis and diversity-oriented synthesis of tunicamycin, taking advantage of the Au(I)-catalyzed glycosylation methodology developed recently in our group. The accessibility of tunicamycin and congeners is essential for the future structure-activity relationship and bioprobe studies.