肠道有益微生物对动物健康发挥着重要作用。它们不仅能防止病原菌入侵或有害微生物的滋扰，而且可以帮助动物生长。鲍是食藻海水动物，也是我国重要的海水养殖对象。但近年来疾病频繁、导致抗生素滥用，鲍鱼养殖业的可持续养殖受到挑战。通过认识鲍肠道微生物，一方面可促进鲍生物学（如食性）与鲍微生态学的研究，另一方面将为肠道微生态调控、疾病控制、提供饲料利用率和生长速率提供可能。前期研究已经发现，鲍肠道有多种特殊的藻类降解菌，并发现其肠道微生物组成特殊，包括柔膜菌、梭杆菌等特殊类群微生物。不同地区不同种类的鲍鱼样品，分析来源不同、品种不同鲍肠道微生物的多样性是否有差别？鲍是否存在核心微生物组？它们与宿主存在怎样的共生关系？鲍是否依赖共生细菌降解海藻？通过高通量测序与生物信息学分析，获得其核心微生物组特征与高丰度菌种的基因组，并通过培养手段验证重要菌种的功能。研究结果将丰富海洋无脊椎动物与微生物的共生关系认识。

Intestine bacteria play an important role in animal health. They not only can prevent the intrusion of microbial pathogens or the interference of non-benefit bacteria, but also promote the growth of their host. Abalone, the typical marine invertebrate, grows on algae that can be served as the sole food source. Abalone nowadays turns to one of the most popular and profitable marine animal product. However, its aquaculture endangered with by the outbreak of diseases, which leads to the abuse of antibiotics. This study on the microbial diversity of abalones of different areas and different species will provide insights into the core microbiome of the abalone and possibly save the abalone raising from attacks of pathogens. We tentatively know that bacteria insides contained members of the bacterial classes like Mollicutes, Fusobacteria and Deltaproteobateria. But what are the differences among the abalones from different species and the abalones far in geographic distance. In addition, what about the core microbome of this animal? And how they interact with their hosts? They at least play a role in algae digestion, and possibly in other aspects. By now, we know little about these processes. In this proposal, the abalone symbiont bacteria will de deciphered by high throughout sequencing and culture cultivation and function verifications. These results would gain deep insights into symbiont relationship between marine invertebrate and bacteria.