Pibocin A和B、fumigaclavine C、9-deacetylfumigaclavine C以及9-deacetoxyfumigaclavine C都属于3，4桥环吲哚类生物碱。生物活性测试显示，pibocin A和B对小鼠的Ehrlich肿瘤细胞具有较好的细胞毒活性，fumigaclavine C及其相关天然产物对人类白血病细胞K562表现出了较强的细胞毒活性。但是，有关这些天然产物的全合成至今还没有报道。本项目拟应用我们自己发展的分子内的Larock吲哚合成构建3,4桥环吲哚骨架的新方法作为关键反应步骤，设计制定新颖、简洁、高效的合成路线以完成pibocin B和fumigaclavine C两类天然产物的首次全合成。开展本课题的研究不仅对丰富吲哚类生物碱的全合成研究具有学术意义，而且对相关先导化合物的发现具有潜在的实用价值。

Pibocin A and B, fumigaclavine C, 9-deacetylfumigaclavine C, and 9-deacetoxyfumigaclavine C all belong to this group of 3,4-fused indole alkaloids. Biological activity tests showed that Pibocin A and B showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells, fumigaclavine C and related natural products showed selectively potent cytotoxicity against human leukemia cells (K562). However, there is no reported for the total synthesis of these natural products up to date. As our goal towards the total synthesis of indole alkaloids, we designed a novel, practical and efficient synthetic strategy for fumigaclavine C, pibocin B and a serious of other natural products based on our recently developed method for the synthesis of 3,4-fused indoles by employing an intramolecular Larock indolization as key step. The value of this research subject is that it enriches the chemistry of indole alkaloids total synthesis, and it has also potential applications in the lead compound discovering.