具有重要生物活性的寡糖及其缀合物的合成研究

本项目针对寡糖及其缀合物合成中的关键科学问题，在项目组已取得的大量前期工作积累的基础上，以寡糖及其缀合物的高效合成为导向，计划开展以下内容的研究：1）发展新的高效、高选择性的糖基化方法，发展或完善新的寡糖高效组装策略；2）将发展的方法和策略应用于若干具有重要生物活性和潜在药用价值的复杂寡糖及其衍生物的合成，并对其生物活性进行评价，发现寡糖类先导化合物；3）发展用于蛋白质修饰的新的生物正交化学反应，用于糖蛋白的合成，为其相应的功能研究奠定基础。本项目的实施将促进我国糖化学研究的发展，并带动糖化学生物学和糖类药物研究的进步。

To tackle the major problems of oligosaccharide and glycoconjugate synthesis, based on our previous achievements, towards highly efficient synthesis of oligosaccharides and glycoconjugates, in this proposal we plan to accomplish the following work: 1) the development of new efficient and stereoselective glycosylation methods, the development and improvement of oligosaccharide assembly strategies; 2) the syntheses of some complex oligosaccharides and their derivatives with biological importance and therapeutical potential by using our new methods or strategies, evaluation of their bioactivities, and discovery of oligosaccharide lead compounds; 3) the development of new bioorthogonal reactions and their applications to glycoprotein synthesis, benefiting the functional studies on the modified proteins. The implement of this project will promote the development of carbohydrate chemistry, chemical glycobiology, and carbohydrate-based drug discovery.