修饰核酸对信号转导过程的影响研究

核酸在细胞信号转导过程中起着重要作用。由于核酸结构多态性的存在，在生物体内，核酸会呈现出不同结构特点，并随着生命活动的进行处于动态变化之中，这些结构之间的相互转变往往会造成相应信号和生理功能的改变。因此，从分子水平研究并调控这些结构变化及核酸相关信号通路，并以化学小分子作为探针进行调控具有重要的理论价值和应用潜力。本项目拟针对修饰核酸，围绕氧化损伤和表观遗传修饰——这两种最重要的核酸修饰，对核酸结构和功能的影响，通过化学小分子与它们的相互作用来探索和调控细胞相关信号转导过程，揭示生命过程规律，推动生物学和医药行业的发展。

Nucleic acids play important roles in cell signaling. Due to their polymorphism and transformation dynamics, different nucleic acids' secondary structures in vivo would affect their activities in some important biological process and also impact their interactions with corresponding protein factors as well, bringing in different process of cell signaling. Thus, studies on the mechanism of these cell signaling process are meaningful. In this project, we would focus on the structural and effect of the modified nucleic acids, especially the modifications' effect on nucleic acids' structure and biological function, and consequential changes in cell signaling. We would take the advantages of small molecules, using them to probe, regulate and detect the signaling change upon the nucleic acids' modification.