水产品中渔药残留检测意义重大，其污染直接危害环境安全和国人健康，也冲击国际贸易和产业经济。但渔药残留检物质种类繁多、含量水平低微、共存于各种复杂的基质里，其检测面临严峻挑战，是一瓶颈问题。本项目将从样品的提取富集入手，建立高灵敏的精准定量分析与快速检测新方法。拟借助分子设计，自主合成功能化有机-无机杂化新材料，再结合功能化修饰、组装及固载，实现对水产品中痕量渔药残留物的分离富集和识别检测。关键研究包括：1、功能化笼型倍半硅氧烷有机-无机杂化材料、渔药残留样品前处理介质、基于笼型倍半硅氧烷有机-无机杂化材料的特异荧光探针等的研制；2、水产品中渔药残留的色谱/质谱定量分析和现场荧光快速检测新方法的建立与应用。该项目既针对国计民生需求，又着力于环境分析化学的前沿，具有学术和应用双重价值，希望能尽早实施。其成功实施将有助于提升我国水产品中渔药残留快检及精准检测技术的核心竞争力。

Analysis of aquatic product pollution from fishery drug residues in urgent required but short of methods because the pollution impacts on environments and human health, and affects the economic interests of the industry and international trade. This proposal aims at the establishment of sensing approaches for accurate quantitative analysis and rapid detection of fishery drug residues based novel sample preparation techniques. This is a bottleneck problem because fishery drug residues include a variety of trace or ultra-trace components buried in highly complex aquatic product matrices. The studies include the synthesis of new functional polyhedral oligomeric silsesquioxane-organic/inorganic hybrid materials (POSS-OIHMs) after molecular design, and POSS-OIHMs-based sample-enriching media and fluorescent probes; and establishment of methods for in situ sensing detection or off site chromatographic/mass spectrometric analysis of trace fishery drug residues in complex aquatic products. These researches not only touch the agricultural production, its economy and people's livelihood but also concern with the frontier field of environmental analysis, possibly able to enhance the core competitiveness of China in the field of aquatic products. It is worth of initiation as soon as possible.