Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.
Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.
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DOI：
10.1007/s10519-020-10005-z
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发表时间：
2020-09
影响因子：
2.6
通讯作者：
Williams PT
中科院分区：
文献类型：
--
作者：
Williams PT
据报道，酒精使用的遗传遗传率（h2）在农村居民、婚姻破裂、社会经济地位低下、未婚或与父母缺乏亲密关系或宗教教养的女孩、受教育程度较低的男性以及同龄人饮酒的青少年中更大。然而，这些都是大量饮酒的危险因素，更大的遗传可能是由于分位数依赖的表达性，即，h2取决于表型（酒精摄入量）相对于其分布是高还是低。分位数回归显示，从后代-父母回归斜率估计的h2从最低到最高克/天的酒精消耗量显著增加（0.006± 0.001%，P=1.1x10−7）。样本分布第90百分位数的遗传度（0.557±0.116）是第10百分位数（0.122±0.037）的4.5倍。其他大量营养素摄入量的遗传力不依赖于分位数。因此，分位数依赖的表现力可以解释与高酒精消费的风险因素相关的较高的估计遗传力。
Genetic heritability (h2) of alcohol use is reported to be greater in rural dwellers, distressed marriages, low socioeconomic status, in girls who are unmarried or lacking closeness with their parents or religious upbringing, in less-educated men, and in adolescents with peers using alcohol. However, these are all risk factors for heavy drinking, and the greater heritability could be due to quantile-dependent expressivity, i.e., h2 dependent upon whether the phenotype (alcohol intake) is high or low relative to its distribution. Quantile regression showed that h2 estimated from the offspring-parent regression slope increased significantly from lowest to highest gram/day of alcohol consumption (0.006±0.001 per percent, P=1.1x10−7). Heritability at the 90th percentile of the sample distribution (0.557±0.116) was 4.5-fold greater than at the 10th percentile (0.122±0.037). Heritabilities for intakes of other macronutrients were not quantile-dependent. Thus quantile-dependent expressivity may explain the higher estimated heritability associated with risk factors for high alcohol consumption.
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DOI：
10.1111/ajad.12478
发表时间：
2017-08
期刊：
The American journal on addictions
影响因子：
--
作者：
Chartier KG;Karriker-Jaffe KJ;Cummings CR;Kendler KS
通讯作者：
Kendler KS
影响因子：
10.6
作者：
Covault, Jonathan;Tennen, Howard;Kranzler, Henry R.
通讯作者：
Kranzler, Henry R.
DOI：
10.1111/j.1530-0277.2007.00356.x
发表时间：
2007-05-01
影响因子：
3.2
作者：
Grant, Julia D.;Heath, Andrew C.;Martin, Nicholas G.
通讯作者：
Martin, Nicholas G.
DOI：
10.15288/jsa.2003.64.182
发表时间：
2003-03-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Cleveland, HH;Wiebe, RP
通讯作者：
Wiebe, RP
影响因子：
5
作者：
Johnson, Wendy;Kyvik, Kirsten Ohm;Deary, Ian J.
通讯作者：
Deary, Ian J.