Serum copper levels are associated with bone mineral density and total fracture.
Serum copper levels are associated with bone mineral density and total fracture.
复制标题
血清铜水平与骨矿物质密度和完全骨折有关。
DOI：
10.1016/j.jot.2018.05.001
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发表时间：
2018-07
影响因子：
6.6
通讯作者：
Dai K
中科院分区：
文献类型：
--
作者：
Qu X;He Z;Qiao H;Zhai Z;Mao Z;Yu Z;Dai K
铜缺乏和过量都与不良健康影响有关。然而，将铜与骨矿物质密度（BMD）和总骨折联系起来的证据有限。这项具有全国代表性的横断面研究招募了来自美国国家健康和营养调查（2011-2014）的参与者。使用未调整和多变量调整的logistic回归分析和两段线性回归模型与平滑函数，我们评估了722名参与者的血清铜水平，骨密度和总骨折之间的关联。研究样本（n = 722，平均年龄：56.47 ± 11.55岁）代表了一个人群，其中47.2%为男性; 43.91%为非西班牙裔白色人，18.84%为非西班牙裔黑人，13.71%为墨西哥裔美国人; 25.9%为全骨折。在多变量logistic回归分析中，血清铜浓度最低类别（<98.5 μg/dL）的个体比第二浓度类别（98.5-114 μg/dL）的个体股骨总BMD低0.049 g/cm 2，股骨颈BMD低0.045 g/cm 2。血清铜浓度最高类别（≥134 μg/dL）的个体发生完全骨折的风险比第二浓度类别的个体增加约4倍。多因素Logistic回归分析显示，血清铜水平每升高10 μg/dL与骨折总发生率无显著相关性（均p > 0.05）。然而，观察到男性和女性之间血清铜水平与总骨折之间的差异相关性（男性比值比= 1.81，95%置信区间1.08-3.03，p = 0.026;女性比值比= 1.07，95%置信区间0.86-1.32，p = 0.552）。中等的血清铜水平对骨骼健康至关重要。较低的血清铜水平与股骨和股骨颈的BMD降低显著相关。较高的血清铜水平与总骨折的增加显著相关，尤其是在男性中。血清铜浓度对骨密度和总骨折的影响可以为含铜补充剂和生物材料的临床应用提供见解。
Both copper deficiency and overexposure have been associated with adverse health effects. Evidence linking copper to bone mineral density (BMD) and total fracture, however, is limited. This nationally representative cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (2011–2014) in the United States. Using unadjusted and multivariate adjusted logistic regression analyses and a two-piecewise linear regression model with a smoothing function, we evaluated the associations between serum copper levels, bone mineral density and total fracture in 722 participants. The study sample (n = 722, mean age: 56.47 ± 11.55 y) represented a population of which 47.2% were men; 43.91% were non-Hispanic white, 18.84% non-Hispanic black and 13.71% Mexican American; 25.9% had total fracture. In the multivariate logistic regression analysis, individuals in the lowest category (<98.5 μg/dL) of serum copper concentration had 0.049 g/cm2 lower total femur BMD and 0.045 g/cm2 lower femoral neck BMD than those in the second concentration category (98.5–114 μg/dL). Individuals in the highest category (≥134 μg/dL) of serum copper concentration had an approximately 4-fold increase in the risk of total fracture than those in the second concentration category. There were no significant associations between per 10 μg/dL increases in serum copper levels and total fracture in multivariate logistic regression analysis after multivariate adjustment (all p > 0.05). However, a differential association between serum copper levels and total fractures between men and women was observed (odds ratio = 1.81, 95% confidence interval 1.08–3.03, p = 0.026 for men and odds ratio = 1.07, 95% confidence interval 0.86–1.32, p = 0.552 for women). Moderate serum copper levels are critically important for bone health. Lower serum copper levels are significantly associated with decreased BMD in the total femur and femoral neck. Higher serum copper levels are significantly associated with increased total fracture, especially in men. The impact of serum copper concentrations on bone mineral density and total fracture can provide insights into clinical application of copper-containing supplements and biomaterials.
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影响因子：
3
作者：
Esfahani, Seyed Taher;Hamidian, Mohammad Reza;Haddadi, Marzieh
通讯作者：
Haddadi, Marzieh
影响因子：
3.9
作者：
MASSIE, HR;AIELLO, VR;ARMSTRONG, T
通讯作者：
ARMSTRONG, T
影响因子：
6.6
作者：
Gallo J;Raska M;Kriegova E;Goodman SB
通讯作者：
Goodman SB
影响因子：
9.7
作者：
Bari, Alessandra;Bloise, Nora;Vitale-Brovarone, Chiara
通讯作者：
Vitale-Brovarone, Chiara
DOI：
10.1016/j.jtemb.2015.06.005
发表时间：
2015-01-01
影响因子：
3.5
作者：
Dermience, Michael;Lognay, Georges;Goyens, Philippe
通讯作者：
Goyens, Philippe