Neurogenesis in the chronic lesions of multiple sclerosis.
Neurogenesis in the chronic lesions of multiple sclerosis.
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DOI：
10.1093/brain/awn157
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Trapp BD
中科院分区：
文献类型：
--
作者：
Chang A;Smith MC;Yin X;Fox RJ;Staugaitis SM;Trapp BD
成人大脑中的皮质下白质包含一组帮助调节脑血流的中间神经元。我们研究了皮质下白质脱髓鞘后这些神经元的命运。应用免疫组织化学方法检测9例多发性硬化症患者和4例对照组的7例急性和59例慢性脱髓鞘病变的皮质下白质神经元。59个急性多发性硬化症病变中的7个和44个慢性多发性硬化症病变中有明显的神经元丢失。与周围正常白质相比，其余15例慢性多发性硬化症病变的成熟中间神经元密度增加了72%，突触密度增加，细胞具有未成熟神经元的表型特征。神经元密度增加的损伤区域包含形态上不同的激活的小胶质细胞群。与脱髓鞘病变相邻的脑室下区也包含具有神经元前体表型的细胞的增加。这些结果支持多发性硬化症大脑中脱髓鞘皮质下白质病变的亚群中的神经发生。
Subcortical white matter in the adult human brain contains a population of interneurons that helps regulate cerebral blood flow. We investigated the fate of these neurons following subcortical white matter demyelination. Immunohistochemistry was used to examine neurons in normal-appearing subcortical white matter and seven acute and 59 chronic demyelinated lesions in brains from nine patients with multiple sclerosis and four controls. Seven acute and 44 of 59 chronic multiple sclerosis lesions had marked neuronal loss. Compared to surrounding normal-appearing white matter, the remaining 15 chronic multiple sclerosis lesions contained a 72% increase in mature interneuron density, increased synaptic densities and cells with phenotypic characteristics of immature neurons. Lesion areas with increased neuron densities contained a morphologically distinct population of activated microglia. Subventricular zones contiguous with demyelinated lesions also contained an increase in cells with phenotypes of neuronal precursors. These results support neurogenesis in a subpopulation of demyelinated subcortical white matter lesions in multiple sclerosis brains.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
7.8
作者：
Aguirre, Adan A;Chittajallu, Ramesh;Belachew, Shibeshih;Gallo, Vittorio
通讯作者：
Gallo, Vittorio
影响因子：
2.5
作者：
KOSTOVIC, I;STEFULJFUCIC, A;DELALLE, I
通讯作者：
DELALLE, I
影响因子：
3.3
作者：
BO, L;MORK, S;TRAPP, BD
通讯作者：
TRAPP, BD
DOI：
10.1016/s0169-328x(98)00040-0
发表时间：
1998-06-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Ito, D;Imai, Y;Kohsaka, S
通讯作者：
Kohsaka, S