Lateral entorhinal cortex lesions impair odor-context associative memory in male rats.
Lateral entorhinal cortex lesions impair odor-context associative memory in male rats.
复制标题
外侧内嗅皮层损伤损害雄性大鼠的气味背景联想记忆。
DOI：
10.1002/jnr.25027
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发表时间：
2022-04
影响因子：
4.2
通讯作者：
Ainge, James A.
中科院分区：
文献类型：
--
作者：
Persson, Bjorn M.;Ambrozova, Veronika;Duncan, Stephen;Wood, Emma R.;O'Connor, Akira R.;Ainge, James A.
关键词：
外侧内嗅皮层（LEC）已被假设为处理非空间，项目信息，结合来自内侧内嗅皮层的空间信息，形成情节记忆的海马。然而，最近的研究表明，LEC在整合海马之前的情景记忆功能中发挥作用。虽然LEC的确切作用尚不清楚，但解剖学研究表明，LEC是整合多感官信息的理想枢纽。目前的研究测试LEC在整合信息中的作用是否延伸到长期的多模态项目上下文关联。在实验1中，对雄性大鼠进行了情境依赖性气味辨别任务的训练，其中两种不同的情境作为正确气味的线索。大鼠预先训练的任务，然后接受双侧兴奋毒性LEC或假病变。手术后，对大鼠进行了先前学习的气味背景关联测试。对照组大鼠表现出良好的记忆力，以前学到的协会，但大鼠与LEC病变表现出显着受损的性能相对于自己的术前性能和对照组大鼠。实验2继续测试实验1中的损伤是否是LEC损伤单独损害气味或上下文记忆保持的结果。雄性大鼠接受了简单的气味和背景辨别任务的训练，这些任务不需要整合特征来解决。手术后，LEC和对照组大鼠表现出良好的记忆先前学习的气味和内容。这些数据表明，LEC对于长期气味背景联想记忆至关重要。损伤侧内嗅皮层的大鼠对气味和背景的记忆受损，而对单个项目的记忆不受影响。这表明关联信息的整合发生在外侧内嗅皮层和海马的水平上。
Lateral entorhinal cortex (LEC) has been hypothesized to process nonspatial, item information that is combined with spatial information from medial entorhinal cortex to form episodic memories within the hippocampus. Recent studies, however, have demonstrated that LEC has a role in integrating features of episodic memory prior to the hippocampus. While the precise role of LEC is still unclear, anatomical studies show that LEC is ideally placed to be a hub integrating multisensory information. The current study tests whether the role of LEC in integrating information extends to long‐term multimodal item‐context associations. In Experiment 1, male rats were trained on a context‐dependent odor discrimination task, where two different contexts served as the cue to the correct odor. Rats were pretrained on the task and then received either bilateral excitotoxic LEC or sham lesions. Following surgery, rats were tested on the previously learned odor‐context associations. Control rats showed good memory for the previously learned association but rats with LEC lesions showed significantly impaired performance relative to both their own presurgery performance and to control rats. Experiment 2 went on to test whether impairments in Experiment 1 were the result of LEC lesions impairing either odor or context memory retention alone. Male rats were trained on simple odor and context discrimination tasks that did not require integration of features to solve. Following surgery, both LEC and control rats showed good memory for previously learned odors and contexts. These data show that LEC is critical for long‐term odor‐context associative memory. Rats with lesions of lateral entorhinal cortex have impaired memory for associations of odors and contexts while their memory for individual items is unaffected. This suggests that integration of associative information occurs at the level of lateral entorhinal cortex as well as the hippocampus.
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