Epidemiology of gastroesophageal reflux disease in Asia: a systematic review.

Epidemiology of gastroesophageal reflux disease in Asia: a systematic review.
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DOI:
10.5056/jnm.2011.17.1.14
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发表时间:
2011-01
影响因子:
3.4
通讯作者:
Jung HK
Jung HK
中科院分区:
医学2区
文献类型:
--
作者:
Jung HK

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种族和地理差异是研究疾病频率的重要因素,因为它们可能突出环境或遗传对病因的影响。我们根据胃食管反流病(GERD)的定义、研究背景、发表年份和地理区域,检索了已发表的有关亚洲胃食管反流病(GERD)流行病学特征的研究。从基于人群的研究中,东亚地区基于症状的胃食管反流的患病率在2005年之前为2.5%-4.8%,2005年至2010年为5.2%-8.5%。2005年以后,东南亚和西亚的失业率为6.3% ~ 18.3%,远高于东亚地区。医学检查参与者中有内窥镜反流性食管炎的可靠流行病学数据。内镜下反流性食管炎在东亚的患病率从2000年前的3.4%-5.0%上升到2005年后的4.3%-15.7%。虽然只有有限的研究,但在亚洲,胃食管反流组的食管外综合征患病率高于对照组。Barrett食道的患病率在健康检查参与者中为0.06%-0.84%,而在转诊医院环境中为0.31%-2.00%。总之,在亚洲国家,基于症状的反流性食管反流和内镜下反流性食管炎的患病率有所增加。然而,巴雷特食管在亚洲的患病率并没有改变,仍然很少见。
Ethnic and geographical differences are important factors in studying disease frequencies, because they may highlight the environmental or genetic influences in the etiology. We retrieved the studies which have been published regarding the epidemiologic features of gastroesophageal reflux disease (GERD) in Asia, based on the definitions of GERD, study settings, publication years and geographical regions. From the population-based studies, the prevalence of symptom-based GERD in Eastern Asia was found to be 2.5%-4.8% before 2005 and 5.2%-8.5% from 2005 to 2010. In Southeast and Western Asia, it was 6.3%-18.3% after 2005, which was much higher than those in Eastern Asia. There were robust epidemiologic data of endoscopic reflux esophagitis in medical check-up participants. The prevalence of endoscopic reflux esophagitis in Eastern Asia increased from 3.4%-5.0% before 2000, to 4.3%-15.7% after 2005. Although there were only limited studies, the prevalence of extra-esophageal syndromes in Asia was higher in GERD group than in controls. The prevalence of Barrett's esophagus was 0.06%-0.84% in the health check-up participants, whereas it was 0.31%-2.00% in the referral hospital settings. In summary, the prevalence of symptom-based GERD and endoscopic reflux esophagitis has increased in Asian countries. However, the prevalence of Barrett's esophagus in Asia has not changed and also still rare.
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