Early Childhood Adverse Experiences, Inferior Frontal Gyrus Connectivity, and the Trajectory of Externalizing Psychopathology.
Early Childhood Adverse Experiences, Inferior Frontal Gyrus Connectivity, and the Trajectory of Externalizing Psychopathology.
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DOI：
10.1016/j.jaac.2017.12.011
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发表时间：
2018-03
影响因子：
13.3
通讯作者：
Luby JL
中科院分区：
文献类型：
--
作者：
Barch DM;Belden AC;Tillman R;Whalen D;Luby JL
儿童早期不良经历（ACE）与内化和外化精神病理学的发展有关。在我们之前的研究中，我们发现ACE可以预测额下回（IFG）体积的减少，IFG是一个对冲动控制和情绪调节很重要的大脑区域。在这里，我们测试的假设，ACE可能会影响儿童的行为结果，通过IFG功能连接的影响，这可能会影响冲动或冒险行为。我们研究了前瞻性评估ACE对儿童IFG连接的影响，以及它们与学龄后期和青春期早期随后精神病理学轨迹的关系，利用从学龄前开始的儿童11年纵向研究的数据，包括儿童和青春期早期的三波静息状态功能连接。ACE预测左右IFG的功能连接。在3波评估中对症状的多水平建模表明，更多的ACE预测了内化和外化症状。然而，改变IFG连接具体预测更大的外化症状随着时间的推移，在童年中期和青春期早期，相比内化症状。纵向建模表明，外化和功能连接之间的关系保持在三个波的功能连接评估。这些研究结果强调了ACE与后来的精神病理学的关系，并表明IFG的连接性，一个已知在冲动控制和情绪调节中发挥重要作用的区域，可能在ACE的风险轨迹中发挥关键作用。然而，需要进一步的工作来了解这些关系是否反映了ACE的直接影响，或者ACE是否是其他可能影响大脑发育和行为的环境或遗传因素的标志物。
Early adverse childhood experiences (ACEs) have been linked to the development of both internalizing and externalizing psychopathology. In our prior work, we found that ACEs predicted reductions in the volume of the inferior frontal gyrus (IFG), a brain region important for impulse control and emotion regulation. Here we tested the hypothesis that ACEs might influence child behavioral outcomes through an impact on IFG functional connectivity, which may influence impulsive or risk-taking behavior. We examined the effects of prospectively assessed ACEs on IFG connectivity in childhood, and their relationship to the trajectory of subsequent psychopathology from late school age and early adolescence, utilizing data from an 11-year longitudinal study of children starting in preschool that included three waves of resting state functional connectivity across childhood and early adolescence. ACEs predicted functional connectivity of both left and right IFG. Multi-level modeling of symptoms across 3 waves of assessments indicated that more ACEs predicted both internalizing and externalizing symptoms. However, altered IFG connectivity specifically predicted greater externalizing symptoms over time in middle childhood and early adolescence, as compared to internalizing symptoms. Longitudinal modeling indicating that the relationships between externalizing and functional connectivity maintained across three waves of functional connectivity assessment. These findings underscore the relationship of ACEs to later psychopathology and suggest that connectivity of the IFG, a region known to play an important role in impulse control and emotion regulation, may play a key role in the risk trajectory of ACEs to externalizing problems. However, further work is needed to understand whether these relationships reflect a direct effect of ACEs or whether ACEs are a marker for other environmental or genetic factors that may also influence brain development and behavior.
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影响因子：
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作者：
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