Treatment Modalities for Acne.
Treatment Modalities for Acne.
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DOI：
10.3390/molecules21081063
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发表时间：
2016-08-13
期刊：
影响因子：
--
通讯作者：
Gerber M
中科院分区：
文献类型：
--
作者：
Fox L;Csongradi C;Aucamp M;du Plessis J;Gerber M
痤疮是一种常见的炎症性皮肤病，影响皮肤的毛囊皮脂腺单位。它可能会产生严重的心理影响，并可能给患者留下严重的皮肤疤痕。有四个公认的病理因素负责痤疮，这也是痤疮治疗的目标。在这篇综述中，讨论了不同的治疗方案，包括局部（即，类维生素A和抗生素）和全身（即，类维生素A、抗生素和激素）治疗。由于公众对更自然和更安全的治疗方案越来越感兴趣，因此还讨论了使用补充和替代药物（CAM）治疗痤疮。还提到了物理疗法的使用，例如粉刺提取、冷冻治疗、冷冻疗法、电烙术、病灶内皮质类固醇和光学治疗。痤疮已被广泛研究的疾病机制以及治疗方案。然而，由于痤疮丙酸杆菌对可用抗生素的耐药性增加，需要新的治疗方法。此外，由于缺乏关于CAM疗法疗效的必要证据，研究人员有必要进一步研究这些治疗方案。
Acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. It can have severe psychological effects and can leave the patient with severe skin scarring. There are four well-recognized pathological factors responsible for acne which is also the target for acne therapy. In this review, different treatment options are discussed, including topical (i.e., retinoids, and antibiotics) and systemic (i.e., retinoids, antibiotics, and hormonal) treatments. Since the general public has been showing an increasing interest in more natural and generally safer treatment options, the use of complementary and alternative medicines (CAM) for treating acne was also discussed. The use of physical therapies such as comedone extraction, cryoslush therapy, cryotherapy, electrocauterization, intralesional corticosteroids and optical treatments are also mentioned. Acne has been extensively researched with regards to the disease mechanism as well as treatment options. However, due to the increasing resistance of Propionibacterium acnes towards the available antibiotics, there is a need for new treatment methods. Additionally, the lack of necessary evidence on the efficacy of CAM therapies makes it necessary for researchers to investigate these treatment options further.
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