A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration.
A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration.
复制标题
掺杂聚吡咯的导电海藻酸钠和羧甲基壳聚糖水凝胶用于周围神经再生
DOI：
10.1039/c8ra01059e
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发表时间：
2018-03-16
期刊：
影响因子：
3.9
通讯作者：
Xu, Pei-Hu
中科院分区：
文献类型：
--
作者：
Bu, Ying;Xu, Hai-Xing;Li, Xin;Xu, Wen-Jin;Yin, Yi-xia;Dai, Hong-lian;Wang, Xiao-bin;Huang, Zhi-Jun;Xu, Pei-Hu
具有导电性能的高分子材料由于其特殊的性能在各自的领域有着良好的应用。然而，它们通常表现出较差的机械性能和生物相容性。在这项工作中，我们提出了一种简单的方法来制备导电海藻酸钠（SA）和羧甲基壳聚糖（CMCS）聚合物水凝胶（SA/CMCS/PPy），可以提供足够的帮助周围神经再生。以d-β-δ-内酯（GDL）和超细碳酸钙（CaCO 3）组成的缓释体系为钙离子交联剂，聚吡咯（PPy）为导电剂，制备了SA/CMCS水凝胶。通过聚吡咯含量调节导电性SA/CMCS/PPy水凝胶的溶胀时间、溶胀比、孔隙率和杨氏模量，其电导率在2.41 × 10 - 5至8.03 × 10 - 3S cm-1之间。通过控制电刺激细胞实验验证了导电水凝胶在细胞生长方面的优势，并将其作为神经导管的填充材料进行了动物实验。SA/CMCS/PPy导电水凝胶具有良好的生物相容性和修复功能，有望在神经组织工程中应用。
Polymer materials with electrically conductive properties have good applications in their respective fields because of their special properties. However, they usually exhibited poor mechanical properties and biocompatibility. In this work, we present a simple approach to prepare conductive sodium alginate (SA) and carboxymethyl chitosan (CMCS) polymer hydrogels (SA/CMCS/PPy) that can provide sufficient help for peripheral nerve regeneration. SA/CMCS hydrogel was cross-linked by calcium ions provided by the sustained release system consisting of d-glucono-δ-lactone (GDL) and superfine calcium carbonate (CaCO3), and the conductivity of the hydrogel was provided by doped with polypyrrole (PPy). Gelation time, swelling ratio, porosity and Young's modulus of the conductive SA/CMCS/PPy hydrogel were adjusted by polypyrrole content, and the conductivity of it was within 2.41 × 10−5 to 8.03 × 10−3 S cm−1. The advantages of conductive hydrogels in cell growth were verified by controlling electrical stimulation of cell experiments, and the hydrogels were also used as a filling material for the nerve conduit in animal experiments. The SA/CMCS/PPy conductive hydrogel showed good biocompatibility and repair features as a bioactive biomaterial, we expect this conductive hydrogel will have a good potential in the neural tissue engineering.
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