Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls.
Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls.
复制标题
DOI：
10.1016/j.reprotox.2012.07.005
复制
发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Weihe P
中科院分区：
文献类型：
--
作者：
Grandjean P;Grønlund C;Kjær IM;Jensen TK;Sørensen N;Andersson AM;Juul A;Skakkebæk NE;Budtz-Jørgensen E;Weihe P
由于多氯联苯（PCBs）被认为会导致内分泌干扰，我们检查了438名来自法罗群岛出生队列的青春期男孩，其中PCB暴露升高。我们测量了14岁时临床检查中脐带血和血清中的PCBs和p，p′-二氯二苯基二氯乙烯（DDE）。较高的产前PCB暴露与较低的血清促黄体激素（LH）和睾酮浓度。此外，性激素结合球蛋白（SHBG）与产前和同期PCB暴露呈正相关。PCB-SHBG关联对协变量调整是稳健的。在结构方程模型中，产前PCB暴露加倍与LH下降6%相关（p = 0.03）。产前暴露于PCB和DDE与睾丸大小和坦纳分期呈微弱、非显着的负相关。DDE与PCB高度相关，与激素水平的相关性略弱。这些研究结果表明，青春期延迟与低血清LH浓度与发展接触非二恶英样多氯联苯可能是由于中央下丘脑-垂体机制。
Because polychlorinated biphenyls (PCBs) are thought to cause endocrine disruption, we examined 438 adolescent boys from a birth cohort in the Faroe Islands, where PCB exposures are elevated. We measured PCBs and p,p′-dichlorodiphenyldichloroethylene (DDE) in cord blood and in serum from clinical examination at age 14. Higher prenatal PCB exposure was associated with lower serum concentrations of both luteinizing hormone (LH) and testosterone. In addition, sex hormone binding globulin (SHBG) was positively associated with both prenatal and concurrent PCB exposures. The PCB-SHBG association was robust to covariate adjustment. In a structural equation model, a doubling in prenatal PCB exposure was associated with a decrease in LH of 6% (p = 0.03). Prenatal exposure to PCB and DDE showed weak, non-significant inverse associations with testicular size and Tanner stage. DDE was highly correlated with PCB and showed slightly weaker associations with the hormone profile. These findings suggest that delayed puberty with low serum-LH concentrations associated with developmental exposure to non dioxin-like PCBs may be due to a central hypothalamo-pituitary mechanism.
登录
查看更多内容
影响因子：
10.4
作者：
Goncharov A;Rej R;Negoita S;Schymura M;Santiago-Rivera A;Morse G;Akwesasne Task Force on the Environment;Carpenter DO
通讯作者：
Carpenter DO
影响因子：
10.4
作者：
Bonde JP;Toft G;Rylander L;Rignell-Hydbom A;Giwercman A;Spano M;Manicardi GC;Bizzaro D;Ludwicki JK;Zvyezday V;Bonefeld-Jørgensen EC;Pedersen HS;Jönsson BA;Thulstrup AM;INUENDO
通讯作者：
INUENDO
影响因子：
10.4
作者：
Longnecker, MP;Wolff, MS;Jensen, AA
通讯作者：
Jensen, AA
DOI：
10.1080/00039896.1992.9938348
发表时间：
1992-05-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
GRANDJEAN, P;WEIHE, P;VIDERO, T
通讯作者：
VIDERO, T
影响因子：
10.4
作者：
Boucher, Olivier;Muckle, Gina;Bastien, Celyne H.
通讯作者：
Bastien, Celyne H.