Deep tissue injury rat model for pressure ulcer research on spinal cord injury.
Deep tissue injury rat model for pressure ulcer research on spinal cord injury.
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DOI：
10.1016/j.jtv.2009.11.009
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发表时间：
2010-05
影响因子：
2.5
通讯作者：
Makhsous M
中科院分区：
文献类型：
--
作者：
Lin F;Pandya A;Cichowski A;Modi M;Reprogle B;Lee D;Kadono N;Makhsous M
已经开发了许多大鼠/小鼠压疮（PU）模型来测试不同的假设，以更深入地了解各种致病风险因素，PU的进展，并评估潜在治疗方式的有效性。最近强调的PU形成的深部组织损伤（DTI）机制受到越来越多的关注，一些研究报告了新开发的DTI动物模型的发现。然而，存在对这些模型的临床相关性和有效性的担忧，特别是当大多数报告的大鼠PU/DTI模型不是建立在SCI动物基础上，并且许多DTI研究没有很好地模拟临床观察时。在这项研究中，我们提出了一个大鼠PU和DTI模型，这是更临床相关的包括慢性SCI条件到大鼠PU模型，并模拟骨突出的作用，在DTI的形成，通过使用植入物的骨组织界面。组织学数据和成像结果证实，在大鼠PU模型中，慢性SCI的状况对压力诱导的组织损伤具有显著影响，并且在大鼠DTI模型中包括模拟的骨突起导致深层肌肉组织中的显著更大的损伤。进一步整合SCI条件和模拟的骨突出将产生大鼠PU/DTI模型，该模型可以更准确地模拟临床现象并产生更多临床相关的研究结果。
Many rat/mouse pressure ulcer (PU) models have been developed to test different hypotheses to gain deeper understanding of various causative risk factors, the progress of PUs, and assessing effectiveness of potential treatment modalities. The recently emphasized deep tissue injury (DTI) mechanisms for PU formation has received increased attention and several studies reported findings on newly developed DTI animal models. However, concerns exist for the clinical relevance and validity of these models, especially when the majority of the reported rat PU/DTI models were not built upon SCI animals and many of the DTI research did not simulate well the clinical observation. In this study, we propose a rat PU and DTI model which is more clinically relevant by including chronic SCI condition into the rat PU model and to simulate the role of bony prominence in DTI formation by using an implant on the bone-tissue interface. Histological data and imaging findings confirmed that the condition of chronic SCI had significant effect on pressure-induced tissue injury in a rat PU model and the including a simulated bony prominence in rat DTI model resulted in significantly greater injury in deep muscle tissue. Further integration of the SCI condition and the simulated bony prominence would result a rat PU/DTI model which can simulate even more accurately the clinical phenomenon and yield research more clinically relevant findings.
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影响因子：
2.9
作者：
Wassermann, Esther;van Griensven, Martijn;Redl, Heinz
通讯作者：
Redl, Heinz
影响因子：
3.6
作者：
Bronneberg, Debbie;Spiekstra, Sander W.;Bouten, Catlijin V. C.
通讯作者：
Bouten, Catlijin V. C.
影响因子：
3.3
作者：
ARMSTRONG, RB;OGILVIE, RW;SCHWANE, JA
通讯作者：
SCHWANE, JA
影响因子：
3.6
作者：
HYODO, A;REGER, SI;BROWNE, EZ
通讯作者：
BROWNE, EZ
脊髓损伤麻醉大鼠皮肤血流运动的后压反应
影响因子：
3.1
作者：
Li, Zengyong;Tam, Eric W. C.;Mak, Arthur F. T.
通讯作者：
Mak, Arthur F. T.