Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics.
Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics.
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DOI：
10.1086/591945
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发表时间：
2008-10-15
影响因子：
6.4
通讯作者：
Griffin, George E.
中科院分区：
文献类型：
--
作者：
Cooper, Philip J.;Moncayo, Ana Lucia;Guadalupe, Irene;Benitez, Susana;Vaca, Maritza;Chico, Martha;Griffin, George E.
土蠕虫感染与对寄生虫抗原和可能受驱虫剂治疗影响的空气过敏原的免疫调节有关。为了研究这一点，我们比较了接受阿苯达唑重复剂量超过一年或没有治疗的儿童之间的细胞因子反应。用蛔虫抗原、屋尘螨和蟑螂变应原培养全血，测定IL-5、IL-13、IFN-γ和IL-10。驱虫治疗与Th 2细胞因子对寄生虫抗原的产生增强有关，但不影响对空气过敏原的反应。这些数据表明，长期治疗可能与抗寄生虫Th 2免疫力增加有关。
Geohelminth infections are associated with a modulation of immunity to parasite antigens and aeroallergens that may be affected by anthelmintic treatment. To investigate this, we compared cytokine responses between children that had received repeated doses of albendazole over a year or no treatment. Whole blood was cultured with Ascaris antigen and house dust mite and cockroach allergens and IL-5, IL-13, IFN-γ, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2 cytokines to parasite antigen, but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased antiparasite Th2 immunity.
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影响因子：
6.4
作者：
Cooper, PJ;Chico, ME;Nutman, TB
通讯作者：
Nutman, TB
影响因子：
3.1
作者：
Cooper, PJ;Chico, M;Nutman, TB
通讯作者：
Nutman, TB
影响因子：
4.6
作者：
Geiger, SM;Massara, CL;Corrêa-Oliveira, R
通讯作者：
Corrêa-Oliveira, R
影响因子：
6.7
作者：
Cooper, P. J.;Barreto, M. L.;Rodrigues, L. C.
通讯作者：
Rodrigues, L. C.
影响因子：
6.4
作者：
Cooper, PJ;Chico, ME;Nutman, TB
通讯作者：
Nutman, TB